Reference - Detail
| RRC ID | 4291 |
|---|---|
| Author | Schott S, Ramos F, Coustham V, Palladino F. |
| Title | HPL-2/HP1 prevents inappropriate vulval induction in Caenorhabditis elegans by acting in both HYP7 and vulval precursor cells. |
| Journal | Genetics |
| Abstract |
A current model for Caenorhabditis elegans vulval cell fate specification is that SynMuv genes act redundantly in the hyp7 hypodermal syncytium to repress the LIN-3/EGF inducer and prevent ectopic vulval induction of vulva precursor cells (VPCs). Here we show that the SynMuv gene hpl-2/HP1 has an additional function in VPCs, where it may act through target genes including LIN-39/Hox. |
| Volume | 181(2) |
| Pages | 797-801 |
| Published | 2009-2-1 |
| DOI | 10.1534/genetics.108.089276 |
| PII | genetics.108.089276 |
| PMID | 19064713 |
| PMC | PMC2644966 |
| MeSH | Animals Caenorhabditis elegans / embryology* Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / antagonists & inhibitors Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Chromosomal Proteins, Non-Histone / genetics Chromosomal Proteins, Non-Histone / physiology* Embryonic Induction / genetics Embryonic Induction / physiology Embryonic Stem Cells / cytology Epidermal Growth Factor / antagonists & inhibitors Epidermal Growth Factor / genetics Epidermal Growth Factor / physiology Female Genes, Helminth Giant Cells / cytology Mutation RNA Interference Vulva / cytology Vulva / embryology* |
| IF | 4.015 |
| Times Cited | 4 |
| WOS Category | GENETICS & HEREDITY |
| Resource | |
| C.elegans | tm1489 |