論文 - 詳細
| RRC ID | 4292 |
|---|---|
| 著者 | Seidel HS, Rockman MV, Kruglyak L. |
| タイトル | Widespread genetic incompatibility in C. elegans maintained by balancing selection. |
| ジャーナル | Science |
| Abstract |
Natural selection is expected to eliminate genetic incompatibilities from interbreeding populations. We have discovered a globally distributed incompatibility in the primarily selfing species Caenorhabditis elegans that has been maintained despite its negative consequences for fitness. Embryos homozygous for a naturally occurring deletion of the zygotically acting gene zeel-1 arrest if their sperm parent carries an incompatible allele of a second, paternal-effect locus, peel-1. The two interacting loci are tightly linked, with incompatible alleles occurring in linkage disequilibrium in two common haplotypes. These haplotypes exhibit elevated sequence divergence, and population genetic analyses of this region indicate that natural selection is preserving both haplotypes in the population. Our data suggest that long-term maintenance of a balanced polymorphism has permitted the incompatibility to persist despite gene flow across the rest of the genome. |
| 巻・号 | 319(5863) |
| ページ | 589-94 |
| 公開日 | 2008-2-1 |
| DOI | 10.1126/science.1151107 |
| PII | 1151107 |
| PMID | 18187622 |
| PMC | PMC2421010 |
| MeSH | Alleles Animals Animals, Genetically Modified Caenorhabditis elegans / embryology Caenorhabditis elegans / genetics* Cloning, Molecular Crosses, Genetic Disorders of Sex Development Embryo, Nonmammalian / physiology Embryonic Development Gene Flow Genes, Helminth Genetic Linkage Genome, Helminth Haplotypes Linkage Disequilibrium Male Molecular Sequence Data Penetrance Polymorphism, Single Nucleotide Selection, Genetic* |
| IF | 41.846 |
| 引用数 | 156 |
| WOS 分野 | GENETICS & HEREDITY |
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| リソース情報 | |
| 線虫 | tm1946 |