| RRC ID |
42936
|
| Author |
Hirata H, Murakami Y, Miyamoto Y, Tosaka M, Inoue K, Nagahashi A, Jakt LM, Asahara T, Iwata H, Sawa Y, Kawamata S.
|
| Title |
ALCAM (CD166) is a surface marker for early murine cardiomyocytes.
|
| Journal |
Cells Tissues Organs
|
| Abstract |
ALCAM (activated leukocyte cell adhesion molecule, CD166) belongs to the immunoglobulin superfamily and is involved in axon guidance, hematopoiesis, immune response and tumor metastasis. During embryogenesis, mRNA encoding ALCAM was expressed in the cardiac crescent and the neural groove at embryonic day (E) 7.75 and predominately in the tubular heart at E8.5. A newly generated monoclonal antibody against the ALCAM molecule (ALC-48) exclusively stained cardiomyocytes at E8.25-10.5. However, ALCAM expression was lost by cardiomyocytes by E12.5 and its expression shifts to a variety of organs during later stages. ALCAM was found to be a prominent surface marker for cardiomyocytes in early embryonic hearts. The transient expression of ALCAM during early developmental stages marks specific developmental stages in cardiomyocyte differentiation.
|
| Volume |
184(3-4)
|
| Pages |
172-80
|
| Published |
2006-1-1
|
| DOI |
10.1159/000099624
|
| PII |
000099624
|
| PMID |
17409743
|
| MeSH |
Activated-Leukocyte Cell Adhesion Molecule / analysis*
Animals
Antibodies, Monoclonal
Biomarkers / analysis
Cell Line
Cell Membrane / ultrastructure
Fetal Heart / cytology
Fetus
Humans
Immunohistochemistry
Kidney
Mice
Muscle Cells / cytology*
Myocardium / cytology*
|
| IF |
2.064
|
| Times Cited |
26
|
|
WOS Category
|
ANATOMY & MORPHOLOGY
DEVELOPMENTAL BIOLOGY
CELL BIOLOGY
|
| Resource |
| Human and Animal Cells |
P19.CL6(RCB1539) |
