| RRC ID |
42957
|
| Author |
Hori M, Kojima H, Nakata S, Konishi H, Kitagawa A, Kawai K.
|
| Title |
A search for the plant ingredients that protect cells from air pollutants and benz[a]pyrene phototoxicity.
|
| Journal |
Drug Chem Toxicol
|
| Abstract |
A diversity of antioxidants and plant ingredients were examined for their protective effect in cultured Balb/c 3T3 cells against ultraviolet A (UVA)-induced cytotoxicities of extracted air pollutants and benz[a]pyrene (B[a]P) in an effort to find effective protectors against the phototoxicity of air pollutants and B[a]P. As has been observed for B[a]P phototoxicity, air pollutants themselves and those previously exposed to UVA light in the absence of cells exhibited faintly weak cytotoxicity, but the toxicity was markedly elevated when they were exposed to UVA light concomitantly with cells. The B[a]P phototoxicity was not eliminated by well-known antioxidants but was markedly diminished by diversity of plant ingredients. Among the plant ingredients tested in the current study, morin, naringin, and quercetin were found to be desirable protectors against B[a]P phototoxicity.
|
| Volume |
30(2)
|
| Pages |
105-16
|
| Published |
2007-1-1
|
| DOI |
10.1080/01480540601186788
|
| PII |
777382426
|
| PMID |
17454027
|
| MeSH |
Air Pollutants / toxicity*
Animals
Antioxidants / pharmacology*
BALB 3T3 Cells
Benzo(a)pyrene / toxicity*
Mice
Plant Extracts / isolation & purification
Plant Extracts / pharmacology*
Plants, Medicinal / chemistry
Ultraviolet Rays / adverse effects*
|
| IF |
2.405
|
| Times Cited |
4
|
|
WOS Category
|
CHEMISTRY, MULTIDISCIPLINARY
PHARMACOLOGY & PHARMACY
TOXICOLOGY
|
| Resource |
| Human and Animal Cells |
|
