| RRC ID |
42967
|
| Author |
Shioi Y, Tamura H, Yokose N, Satoh C, Dan K, Ogata K.
|
| Title |
Increased apoptosis of circulating T cells in myelodysplastic syndromes.
|
| Journal |
Leuk Res
|
| Abstract |
The mechanism of T cell lymphopenia in myelodysplastic syndromes (MDS) is unknown. We investigated apoptosis in freshly isolated and cultured lymphocytes; the latter were used to detect cells not yet apoptotic but destined for apoptosis. Apoptosis increased in both fresh and cultured T cells in MDS compared with those from healthy controls. Furthermore, in lymphopenic MDS patients the lymphocyte count correlated negatively with the degree of T cell apoptosis. MDS T cells showed increased Fas expression. However, in MDS but not in controls, the degree of T cell apoptosis was independent of the Fas expression level, and exogenous anti-Fas antibodies did not modulate T cell apoptosis. Mechanisms other than the Fas-Fas ligand pathway may induce T cell apoptosis in MDS.
|
| Volume |
31(12)
|
| Pages |
1641-8
|
| Published |
2007-12-1
|
| DOI |
10.1016/j.leukres.2007.03.026
|
| PII |
S0145-2126(07)00119-1
|
| PMID |
17485109
|
| MeSH |
Adult
Aged
Aged, 80 and over
Antibodies / pharmacology
Apoptosis*
Case-Control Studies
Humans
Lymphocyte Count
Lymphopenia / etiology*
Middle Aged
Myelodysplastic Syndromes / complications*
T-Lymphocytes / pathology*
fas Receptor / analysis*
fas Receptor / immunology
|
| IF |
2.214
|
| Times Cited |
12
|
|
WOS Category
|
HEMATOLOGY
ONCOLOGY
|
| Resource |
| Human and Animal Cells |
Jurkat(RCB0806) |
