論文 - 詳細
| RRC ID | 4297 |
|---|---|
| 著者 | Simon DJ, Madison JM, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun GB, Kaplan JM, Kim JK. |
| タイトル | The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. |
| ジャーナル | Cell |
| Abstract |
We show that miR-1, a conserved muscle-specific microRNA, regulates aspects of both pre- and postsynaptic function at C. elegans neuromuscular junctions. miR-1 regulates the expression level of two nicotinic acetylcholine receptor (nAChR) subunits (UNC-29 and UNC-63), thereby altering muscle sensitivity to acetylcholine (ACh). miR-1 also regulates the muscle transcription factor MEF-2, which results in altered presynaptic ACh secretion, suggesting that MEF-2 activity in muscles controls a retrograde signal. The effect of the MEF-2-dependent retrograde signal on secretion is mediated by the synaptic vesicle protein RAB-3. Finally, acute activation of levamisole-sensitive nAChRs stimulates MEF-2-dependent transcriptional responses and induces the MEF-2-dependent retrograde signal. We propose that miR-1 refines synaptic function by coupling changes in muscle activity to changes in presynaptic function. |
| 巻・号 | 133(5) |
| ページ | 903-15 |
| 公開日 | 2008-5-30 |
| DOI | 10.1016/j.cell.2008.04.035 |
| PII | S0092-8674(08)00609-0 |
| PMID | 18510933 |
| PMC | PMC2553566 |
| MeSH | Animals Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism* Levamisole / pharmacology MicroRNAs / genetics MicroRNAs / metabolism* Mutation Neuromuscular Junction / metabolism* Nicotinic Agonists / metabolism Receptors, Nicotinic / metabolism Signal Transduction* Transcription Factors / metabolism* Transcription, Genetic rab3 GTP-Binding Proteins / metabolism |
| IF | 38.637 |
| 引用数 | 135 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1635 |