Reference - Detail
| RRC ID | 42974 |
|---|---|
| Author | Maruyama Z, Yoshida CA, Furuichi T, Amizuka N, Ito M, Fukuyama R, Miyazaki T, Kitaura H, Nakamura K, Fujita T, Kanatani N, Moriishi T, Yamana K, Liu W, Kawaguchi H, Nakamura K, Komori T. |
| Title | Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency. |
| Journal | Dev Dyn |
| Abstract |
Runx2 is an essential transcription factor for osteoblast differentiation. However, the functions of Runx2 in postnatal bone development remain to be clarified. Introduction of dominant-negative (dn)-Runx2 did not inhibit Col1a1 and osteocalcin expression in mature osteoblastic cells. In transgenic mice that expressed dn-Runx2 in osteoblasts, the trabecular bone had increased mineralization, increased volume, and features of compact bone, and the expression of major bone matrix protein genes was relatively maintained. After ovariectomy, neither osteolysis nor bone formation was enhanced and bone was relatively conserved. In wild-type mice, Runx2 was strongly expressed in immature osteoblasts but downregulated during osteoblast maturation. These findings indicate that the maturity and turnover rate of bone are determined by the level of functional Runx2 and Runx2 is responsible for bone loss in estrogen deficiency, but that Runx2 is not essential for maintenance of the expression of major bone matrix protein genes in postnatal bone development and maintenance. |
| Volume | 236(7) |
| Pages | 1876-90 |
| Published | 2007-7-1 |
| DOI | 10.1002/dvdy.21187 |
| PMID | 17497678 |
| MeSH | Animals Bone Development / physiology* Bone Resorption / metabolism* Bone and Bones / metabolism* Cell Line Core Binding Factor Alpha 1 Subunit / physiology* Estrogens / deficiency* Mice Mice, Transgenic Osteoblasts / metabolism |
| IF | 3.275 |
| Times Cited | 131 |
| WOS Category | ANATOMY & MORPHOLOGY DEVELOPMENTAL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | MC3T3-E1(RCB1126) C2C12(RCB0987) 10T1/2(RCB0247) |