Reference - Detail
| RRC ID | 43050 |
|---|---|
| Author | Shimadoi S, Takami A, Kondo Y, Okumura H, Nakao S. |
| Title | Macrophage colony-stimulating factor enhances rituximab-dependent cellular cytotoxicity by monocytes. |
| Journal | Cancer Sci |
| Abstract |
Recent studies suggest that monocytes are the dominant effectors by which rituximab induces cell death in B-cell lymphoma. Because macrophage colony-stimulating factor (M-CSF) can enhance the cytotoxicity of monocytes, the authors examined whether this growth factor can enhance their ability to kill lymphoma cells in vitro. Monocytes derived from a healthy volunteer were cultured for 48 h in the presence or absence of M-CSF. Monocytes stimul ated with M-CSF were significantly more cytotoxic to Daudi B-cell lymphomas than unstimulated monocytes. Flow cytometry revealed that M-CSF increased monocyte expression of Fcgamma receptors III and I by 1.6- and 1.5-fold, whereas the expression of Fcgamma receptor II remained unchanged. These results suggest that pretreatment with M-CSF can improve the therapeutic efficacy of rituximab against intractable CD20(+) lymphoma. |
| Volume | 98(9) |
| Pages | 1368-72 |
| Published | 2007-9-1 |
| DOI | 10.1111/j.1349-7006.2007.00544.x |
| PII | CAS544 |
| PMID | 17640305 |
| MeSH | Adjuvants, Immunologic / physiology* Antibodies, Blocking / biosynthesis Antibodies, Blocking / pharmacology Antibodies, Monoclonal / physiology* Antibodies, Monoclonal / therapeutic use Antibodies, Monoclonal, Murine-Derived Antibody-Dependent Cell Cytotoxicity / immunology* Cell Line, Tumor Cells, Cultured Humans Lymphoma / immunology Lymphoma / metabolism Lymphoma / pathology Lymphoma / therapy Macrophage Colony-Stimulating Factor / physiology* Monocytes / immunology* Monocytes / metabolism Receptors, IgG / biosynthesis Receptors, IgG / immunology Rituximab |
| IF | 4.966 |
| Times Cited | 5 |
| WOS Category | ONCOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | MOLT-4(RCB0206) Daudi THP-1(RCB1189) |