| RRC ID |
43050
|
| Author |
Shimadoi S, Takami A, Kondo Y, Okumura H, Nakao S.
|
| Title |
Macrophage colony-stimulating factor enhances rituximab-dependent cellular cytotoxicity by monocytes.
|
| Journal |
Cancer Sci
|
| Abstract |
Recent studies suggest that monocytes are the dominant effectors by which rituximab induces cell death in B-cell lymphoma. Because macrophage colony-stimulating factor (M-CSF) can enhance the cytotoxicity of monocytes, the authors examined whether this growth factor can enhance their ability to kill lymphoma cells in vitro. Monocytes derived from a healthy volunteer were cultured for 48 h in the presence or absence of M-CSF. Monocytes stimul ated with M-CSF were significantly more cytotoxic to Daudi B-cell lymphomas than unstimulated monocytes. Flow cytometry revealed that M-CSF increased monocyte expression of Fcgamma receptors III and I by 1.6- and 1.5-fold, whereas the expression of Fcgamma receptor II remained unchanged. These results suggest that pretreatment with M-CSF can improve the therapeutic efficacy of rituximab against intractable CD20(+) lymphoma.
|
| Volume |
98(9)
|
| Pages |
1368-72
|
| Published |
2007-9-1
|
| DOI |
10.1111/j.1349-7006.2007.00544.x
|
| PII |
CAS544
|
| PMID |
17640305
|
| MeSH |
Adjuvants, Immunologic / physiology*
Antibodies, Blocking / biosynthesis
Antibodies, Blocking / pharmacology
Antibodies, Monoclonal / physiology*
Antibodies, Monoclonal / therapeutic use
Antibodies, Monoclonal, Murine-Derived
Antibody-Dependent Cell Cytotoxicity / immunology*
Cell Line, Tumor
Cells, Cultured
Humans
Lymphoma / immunology
Lymphoma / metabolism
Lymphoma / pathology
Lymphoma / therapy
Macrophage Colony-Stimulating Factor / physiology*
Monocytes / immunology*
Monocytes / metabolism
Receptors, IgG / biosynthesis
Receptors, IgG / immunology
Rituximab
|
| IF |
4.966
|
| Times Cited |
5
|
|
WOS Category
|
ONCOLOGY
|
| Resource |
| Human and Animal Cells |
MOLT-4(RCB0206)
Daudi
THP-1(RCB1189) |
