| RRC ID |
43071
|
| Author |
Nagayama K, Kohno T, Sato M, Arai Y, Minna JD, Yokota J.
|
| Title |
Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution.
|
| Journal |
Genes Chromosomes Cancer
|
| Abstract |
Whole genome scanning of 43 lung cancer cell lines at a 100-kb resolution led to identification of 51 genomic regions with homozygous deletions (HDs). The regions contained 113 genes, including two known tumor suppressor genes, RBl (RB) and CDKN2A (p16), and eight genes previously reported as being candidate tumor suppressor genes, such as PTPRD and LRP1B. Three miRNA genes, MIRNLET7C (let-7c), MIRN99A (hsa-mir-99a), and MIRN125B2 (hsa-mir-125b-2), were also mapped in a region with HD at 21q11-q21. The present study provides a list of protein- and miRNA-encoding genes whose inactivation is possibly involved in lung carcinogenesis.
|
| Volume |
46(11)
|
| Pages |
1000-10
|
| Published |
2007-11-1
|
| DOI |
10.1002/gcc.20485
|
| PMID |
17674361
|
| MeSH |
Carcinoma, Non-Small-Cell Lung / genetics
Carcinoma, Small Cell / genetics
Cell Line, Tumor
Gene Deletion*
Genome*
Homozygote*
Humans
Lung Neoplasms / genetics*
|
| IF |
3.444
|
| Times Cited |
55
|
|
WOS Category
|
GENETICS & HEREDITY
ONCOLOGY
|
| Resource |
| Human and Animal Cells |
|
