| RRC ID |
43101
|
| 著者 |
Kamachi F, Yanai M, Ban HS, Ishihara K, Hong J, Ohuchi K, Hirasawa N.
|
| タイトル |
Involvement of Na+/H+ exchangers in induction of cyclooxygenase-2 by vacuolar-type (H+)-ATPase inhibitors in RAW 264 cells.
|
| ジャーナル |
FEBS Lett
|
| Abstract |
In the mouse macrophage-like cell line RAW 264, vacuolar-type (H(+))-ATPase (V-ATPase) inhibitors, bafilomycin A(1) and concanamycin A, increased the level of cyclooxygenase (COX)-2 protein and its mRNA. The V-ATPase inhibitor-induced expression of COX-2 was suppressed by inhibitors of c-jun N-terminal kinase (JNK) and nuclear factor-kappaB, and by inhibitors of Na(+)/H(+) exchangers (NHEs). The bafilomycin A(1)-induced activation of JNK but not degradation of IkappaB-alpha was suppressed by NHE inhibitors and by an inhibitor of Na(+)/Ca(2+) exchanger SN-6. These results suggested that V-ATPase inhibitors induce the expression of COX-2 via NHE-dependent and -independent pathways.
|
| 巻・号 |
581(24)
|
| ページ |
4633-8
|
| 公開日 |
2007-10-2
|
| DOI |
10.1016/j.febslet.2007.08.055
|
| PII |
S0014-5793(07)00931-3
|
| PMID |
17825820
|
| MeSH |
Animals
Anthracenes / pharmacology
Benzyl Compounds / pharmacology
Cell Line
Cyclooxygenase 2 / genetics
Cyclooxygenase 2 / metabolism*
Enzyme Inhibitors / pharmacology*
Gene Expression Regulation, Enzymologic / drug effects
I-kappa B Kinase / metabolism
JNK Mitogen-Activated Protein Kinases / antagonists & inhibitors
JNK Mitogen-Activated Protein Kinases / metabolism
Macrolides / pharmacology
Mice
NF-kappa B / metabolism
Phosphorylation / drug effects
RNA, Messenger / genetics
Sodium-Hydrogen Exchangers / antagonists & inhibitors
Sodium-Hydrogen Exchangers / metabolism*
Thiazolidines / pharmacology
Vacuolar Proton-Translocating ATPases / antagonists & inhibitors*
Vacuolar Proton-Translocating ATPases / metabolism
|
| IF |
3.057
|
| 引用数 |
4
|
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
RAW 264(RCB0535) |
