論文 - 詳細
| RRC ID | 43105 |
|---|---|
| 著者 | Rahioui I, Laugier C, Balmand S, Da Silva P, Rahbe Y, Gressent F. |
| タイトル | Toxicity, binding and internalization of the pea-A1b entomotoxin in Sf9 cells. |
| ジャーナル | Biochimie |
| Abstract |
PA1b (Pea Albumin 1b) is a peptide toxin lethal for certain insects. This paper shows that the cultured insect cells Sf9 are sensitive to the toxin and display a high-affinity binding site for PA1b. Mammalian cells are not sensitive and no binding activity was detected. Signs of apoptosis of the Sf9 cells were observed in response to the toxin. The use of this cellular model also demonstrated that PA1b was internalized in the cells, via the binding site, raising the new question of the role of this toxin within the cell, and of the mechanisms leading to cell death. |
| 巻・号 | 89(12) |
| ページ | 1539-43 |
| 公開日 | 2007-12-1 |
| DOI | 10.1016/j.biochi.2007.07.021 |
| PII | S0300-9084(07)00197-6 |
| PMID | 17845830 |
| MeSH | Albumins / chemistry* Animals Apoptosis / drug effects Binding Sites Cell Culture Techniques Cell Survival / drug effects Cells, Cultured Endotoxins / chemistry* Endotoxins / isolation & purification Endotoxins / pharmacology Iodine Radioisotopes / metabolism Kinetics Molecular Weight Peas / metabolism* Plant Proteins / chemistry Protein Binding Protein Isoforms / chemistry Spodoptera / cytology* Spodoptera / metabolism* Spodoptera / ultrastructure Temperature Time Factors |
| IF | 3.413 |
| 引用数 | 12 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | |