| RRC ID |
43133
|
| Author |
Efdi M, Ohguchi K, Akao Y, Nozawa Y, Koketsu M, Ishihara H.
|
| Title |
N-trans-feruloyltyramine as a melanin biosynthesis inhibitor.
|
| Journal |
Biol Pharm Bull
|
| Abstract |
In this study, we examined the effect of N-trans-feruloyltyramine (FA) on melanogenesis in mouse B16 melanoma cells. Melanogenesis was inhibited by FA in a dose-dependent manner. FA exhibited a greater potency than kojic acid as a standard inhibitor of melanogenesis. Moreover, treatment of B16 melanoma cells with FA was found to cause marked decreases in the expression levels of tyrosinase. FA-induced downregulation of tyrosinase resulted in suppression of melanin biosynthesis in murine B16 melanoma cells.
|
| Volume |
30(10)
|
| Pages |
1972-4
|
| Published |
2007-10-1
|
| DOI |
10.1248/bpb.30.1972
|
| PII |
JST.JSTAGE/bpb/30.1972
|
| PMID |
17917275
|
| MeSH |
Animals
Annonaceae / chemistry*
Blotting, Western
Cell Line, Tumor
Chromatography, High Pressure Liquid
Coumaric Acids / isolation & purification
Coumaric Acids / pharmacology*
Magnetic Resonance Spectroscopy
Mass Spectrometry
Melanins / antagonists & inhibitors*
Melanins / biosynthesis*
Melanoma, Experimental / drug therapy
Melanoma, Experimental / enzymology
Melanoma, Experimental / pathology
Mice
Monophenol Monooxygenase / metabolism
Plant Extracts / chemistry
Signal Transduction / drug effects
Spectrophotometry, Infrared
Tyramine / analogs & derivatives*
Tyramine / isolation & purification
Tyramine / pharmacology
|
| IF |
1.863
|
| Times Cited |
21
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
|
| Resource |
| Human and Animal Cells |
B16 melanoma(RCB1283) |
