論文 - 詳細
| RRC ID | 43185 |
|---|---|
| 著者 | Kobayashi K, Tada K, Itabe H, Ueno T, Liu PH, Tsutsumi A, Kuwana M, Yasuda T, Shoenfeld Y, de Groot PG, Matsuura E. |
| タイトル | Distinguished effects of antiphospholipid antibodies and anti-oxidized LDL antibodies on oxidized LDL uptake by macrophages. |
| ジャーナル | Lupus |
| Abstract |
Several interpretations have been made regarding the specificity of antiphospholipid antibodies and antibodies against oxidized low-density lipoprotein (oxLDL), but these are still controversial. In the present study, we delineated specificity of these two types of antibodies and analyzed their regulatory effect on oxLDL and/or beta( 2)-glycoprotein I (beta(2)GPI) binding to macrophages. Scavenger receptor-mediated binding of oxLDL (or its beta(2)GPI complexes) to macrophages was observed and the binding was partly prevented by beta( 2)GPI. The IgG monoclonal anti-beta(2)GPI antibody (WB-CAL-1), which was derived from NZW x BXSB F1 mouse (a model of antiphospholipid syndrome), significantly increased the oxLDL/beta(2)GPI binding to macrophages. In contrast, IgM anti-oxLDL natural antibody, EO6 (derived from apoe( -/-) mouse), prevented the binding. Different antigenic specificity of these antibodies to oxLDL and its beta(2)GPI complexes was also confirmed in TLC-ligand blot and ELISA. Thus, IgG anti-beta(2) GPI autoantibodies contribute to lipid metabolism (housekeeping of oxLDL by macrophages) whereas IgM natural anti-oxLDL antibodies may protect against atherogenesis. In addition, in vitro data suggest that relatively high dose of intravenous immunoglobulin preparations (mainly contain IgG anti-oxLDL antibodies) might also prevent atherogenesis by inhibiting the oxLDL binding to macrophages. |
| 巻・号 | 16(12) |
| ページ | 929-38 |
| 公開日 | 2007-1-1 |
| DOI | 10.1177/0961203307084170 |
| PII | 16/12/929 |
| PMID | 18042586 |
| MeSH | Animals Antibodies, Antiphospholipid / physiology* Antibody Specificity Antiphospholipid Syndrome / immunology* Atherosclerosis / immunology* Cell Line Humans Immunoglobulin G / immunology Immunoglobulin G / physiology Immunoglobulin M / immunology Immunoglobulin M / physiology Immunoglobulins, Intravenous / immunology Lipoproteins, LDL / immunology* Lipoproteins, LDL / metabolism Macrophages / immunology Macrophages / physiology* Mice beta 2-Glycoprotein I / physiology* |
| IF | 2.251 |
| 引用数 | 26 |
| WOS 分野 | RHEUMATOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | J774.1(RCB0434) |