RRC ID |
43219
|
著者 |
Kuroyanagi M, Ikeda R, Gao HY, Muto N, Otaki K, Sano T, Kawahara N, Nakane T.
|
タイトル |
Neurite outgrowth-promoting active constituents of the Japanese cypress (Chamaecyparis obtusa).
|
ジャーナル |
Chem Pharm Bull (Tokyo)
|
Abstract |
In the screening of biologically active constituents from woody plants, the methanol extract of leaves of Chamaecyparis obtusa showed potent neurite outgrowth-promoting activity in neuronal PC12 cells. The ethyl acetate-soluble fraction of the methanol extract showed potent activity and was separated by means of various chromatographic methods to give the two new compounds 1 and 2, as well as 11 known lignan and sesquiterpene derivatives. The structures of the new compounds were determined to be 9-O-acetyldihydrosesamin (1) and 9-O-(11-hydroxyeudesman-4-yl)dihydrosesamin (2), respectively, in NMR studies including 2D-NMR experiments. Of the 13 compounds, the known compound hinokinin (5) and the new compound 2 showed potent neurite outgrowth-promoting activity in PC 12 cells.
|
巻・号 |
56(1)
|
ページ |
60-3
|
公開日 |
2008-1-1
|
DOI |
10.1248/cpb.56.60
|
PII |
JST.JSTAGE/cpb/56.60
|
PMID |
18175976
|
MeSH |
4-Butyrolactone / analogs & derivatives*
4-Butyrolactone / chemistry
4-Butyrolactone / isolation & purification
4-Butyrolactone / pharmacology
Animals
Benzodioxoles
Chamaecyparis / chemistry*
Dioxoles / chemistry
Dioxoles / isolation & purification*
Dioxoles / pharmacology*
Lignans / chemistry
Lignans / isolation & purification*
Lignans / pharmacology*
Molecular Structure
Nerve Growth Factor / chemistry
Nerve Growth Factor / isolation & purification*
Nerve Growth Factor / pharmacology*
Neurites / drug effects*
PC12 Cells
Plant Leaves / chemistry
Plants, Medicinal / chemistry*
Rats
|
IF |
1.416
|
引用数 |
14
|
WOS 分野
|
CHEMISTRY, MULTIDISCIPLINARY
PHARMACOLOGY & PHARMACY
CHEMISTRY, MEDICINAL
|
リソース情報 |
ヒト・動物細胞 |
|