RRC ID 43219
著者 Kuroyanagi M, Ikeda R, Gao HY, Muto N, Otaki K, Sano T, Kawahara N, Nakane T.
タイトル Neurite outgrowth-promoting active constituents of the Japanese cypress (Chamaecyparis obtusa).
ジャーナル Chem Pharm Bull (Tokyo)
Abstract In the screening of biologically active constituents from woody plants, the methanol extract of leaves of Chamaecyparis obtusa showed potent neurite outgrowth-promoting activity in neuronal PC12 cells. The ethyl acetate-soluble fraction of the methanol extract showed potent activity and was separated by means of various chromatographic methods to give the two new compounds 1 and 2, as well as 11 known lignan and sesquiterpene derivatives. The structures of the new compounds were determined to be 9-O-acetyldihydrosesamin (1) and 9-O-(11-hydroxyeudesman-4-yl)dihydrosesamin (2), respectively, in NMR studies including 2D-NMR experiments. Of the 13 compounds, the known compound hinokinin (5) and the new compound 2 showed potent neurite outgrowth-promoting activity in PC 12 cells.
巻・号 56(1)
ページ 60-3
公開日 2008-1-1
DOI 10.1248/cpb.56.60
PII JST.JSTAGE/cpb/56.60
PMID 18175976
MeSH 4-Butyrolactone / analogs & derivatives* 4-Butyrolactone / chemistry 4-Butyrolactone / isolation & purification 4-Butyrolactone / pharmacology Animals Benzodioxoles Chamaecyparis / chemistry* Dioxoles / chemistry Dioxoles / isolation & purification* Dioxoles / pharmacology* Lignans / chemistry Lignans / isolation & purification* Lignans / pharmacology* Molecular Structure Nerve Growth Factor / chemistry Nerve Growth Factor / isolation & purification* Nerve Growth Factor / pharmacology* Neurites / drug effects* PC12 Cells Plant Leaves / chemistry Plants, Medicinal / chemistry* Rats
IF 1.416
引用数 14
WOS 分野 CHEMISTRY, MULTIDISCIPLINARY PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL
リソース情報
ヒト・動物細胞