論文 - 詳細
| RRC ID | 43257 |
|---|---|
| 著者 | Suenaga F, Hatsushika K, Takano S, Ando T, Ohnuma Y, Ogawa H, Nakao A. |
| タイトル | A possible link between resveratrol and TGF-beta: resveratrol induction of TGF-beta expression and signaling. |
| ジャーナル | FEBS Lett |
| Abstract |
Resveratrol, a polyphenolic compound found in the skin of red fruits, exhibits anti-inflammatory, anti-oxidative, and anti-proliferative characteristics. Transforming growth factor-beta (TGF-beta) is a pleiotropic cytokine that also displays such properties. We therefore hypothesized that there might be a functional link between resveratrol and TGF-beta. This study reports that resveratrol increased transcription of the TGF-beta2 gene, enhanced the production of TGF-beta2 protein, and activated Smad signaling in an autocrine manner in A549 human lung epithelial cell line. Thus, some of the beneficial effects of resveratrol on human health might be mediated, in part, through its effects on TGF-beta expression and signaling. |
| 巻・号 | 582(5) |
| ページ | 586-90 |
| 公開日 | 2008-3-5 |
| DOI | 10.1016/j.febslet.2008.01.024 |
| PII | S0014-5793(08)00049-5 |
| PMID | 18242191 |
| MeSH | Autocrine Communication / drug effects Cell Line, Tumor Epithelial Cells / drug effects Epithelial Cells / metabolism Gene Expression Regulation / drug effects Humans Kinetics Lung / cytology Lung / drug effects Lung / metabolism Phosphorylation / drug effects Promoter Regions, Genetic / genetics RNA, Messenger / genetics RNA, Messenger / metabolism Receptors, Estrogen / metabolism Resveratrol Signal Transduction / drug effects* Smad3 Protein / metabolism Stilbenes / pharmacology* Transforming Growth Factor beta2 / genetics* Transforming Growth Factor beta2 / metabolism* |
| IF | 3.057 |
| 引用数 | 23 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | |