論文 - 詳細
| RRC ID | 43264 |
|---|---|
| 著者 | Hansman GS, Oka T, Sakon N, Takeda N. |
| タイトル | Antigenic diversity of human sapoviruses. |
| ジャーナル | Emerg Infect Dis |
| Abstract |
Sapovirus (SaV) is a causative agent of gastroenteritis. On the basis of capsid protein (VP1) nucleotide sequences, SaV can be divided into 5 genogroups (GI-GV), of which the GI, GII, GIV, and GV strains infect humans. SaV is uncultivable, but expression of recombinant VP1 in insect cells results in formation of viruslike particles (VLPs) that are antigenically similar to native SaV. In this study, we newly expressed SaV GII and GIV VLPs to compare genetic and antigenic relationships among all human SaV genogroups. Hyperimmune antiserum samples against VLPs reacted strongly with homologous VLPs. However, several antiserum samples weakly cross-reacted against heterologous VLPs in an antibody ELISA. Conversely, an antigen ELISA showed that VLPs of SaV in all human genogroups were antigenically distinct. These findings indicate a likely correspondence between SaV antigenicity and VP1 genogrouping and genotyping. |
| 巻・号 | 13(10) |
| ページ | 1519-25 |
| 公開日 | 2007-10-1 |
| DOI | 10.3201/eid1310.070402 |
| PMID | 18258001 |
| PMC | PMC2851512 |
| MeSH | Caliciviridae Infections / classification Caliciviridae Infections / genetics* Capsid Proteins / genetics Gastroenteritis / virology* Genotype Humans Phylogeny Sapovirus / classification Sapovirus / genetics* Sequence Analysis, RNA |
| IF | 6.259 |
| 引用数 | 22 |
| WOS 分野 | INFECTIOUS DISEASES IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Policy sources |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | |