RRC ID |
43269
|
著者 |
Kang MS, Hirai S, Goto T, Kuroyanagi K, Lee JY, Uemura T, Ezaki Y, Takahashi N, Kawada T.
|
タイトル |
Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation.
|
ジャーナル |
Biochem Biophys Res Commun
|
Abstract |
Obesity is characterized by an enhanced infiltration of macrophages to adipose tissues, which is closely associated with the low-grade inflammatory state and obesity-related pathologies such as type 2 diabetes and cardiovascular diseases. We showed here that dehydroabietic acid (DAA) is a potent PPARalpha/gamma dual activator. Furthermore, we examined the anti-inflammatory effects of DAA in stimulated macrophages and in the coculture of macrophages and adipocytes. DAA significantly suppressed the production of proinflammatory mediators such as MCP-1, TNF-alpha, and NO in stimulated RAW 264 macrophages and in the coculture of RAW 264 macrophages and 3T3-L1 adipocytes. These results suggest that DAA is a valuable medicinal and food component for improving inflammatory changes associated with obesity-related diabetes.
|
巻・号 |
369(2)
|
ページ |
333-8
|
公開日 |
2008-5-2
|
DOI |
10.1016/j.bbrc.2008.02.002
|
PII |
S0006-291X(08)00240-4
|
PMID |
18267111
|
MeSH |
3T3-L1 Cells
Abietanes / administration & dosage*
Adipocytes / drug effects
Adipocytes / immunology*
Animals
Anti-Inflammatory Agents / administration & dosage
Cell Line
Inflammation / immunology*
Inflammation / pathology
Inflammation / prevention & control*
Ligands
Macrophages / drug effects
Macrophages / immunology*
Mice
PPAR alpha / immunology*
PPAR gamma / immunology*
|
IF |
2.985
|
引用数 |
69
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
リソース情報 |
ヒト・動物細胞 |
RAW 264(RCB0535) |