RRC ID 43269
Author Kang MS, Hirai S, Goto T, Kuroyanagi K, Lee JY, Uemura T, Ezaki Y, Takahashi N, Kawada T.
Title Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation.
Journal Biochem. Biophys. Res. Commun.
Abstract Obesity is characterized by an enhanced infiltration of macrophages to adipose tissues, which is closely associated with the low-grade inflammatory state and obesity-related pathologies such as type 2 diabetes and cardiovascular diseases. We showed here that dehydroabietic acid (DAA) is a potent PPARalpha/gamma dual activator. Furthermore, we examined the anti-inflammatory effects of DAA in stimulated macrophages and in the coculture of macrophages and adipocytes. DAA significantly suppressed the production of proinflammatory mediators such as MCP-1, TNF-alpha, and NO in stimulated RAW 264 macrophages and in the coculture of RAW 264 macrophages and 3T3-L1 adipocytes. These results suggest that DAA is a valuable medicinal and food component for improving inflammatory changes associated with obesity-related diabetes.
Volume 369(2)
Pages 333-8
Published 2008-5-2
DOI 10.1016/j.bbrc.2008.02.002
PII S0006-291X(08)00240-4
PMID 18267111
MeSH 3T3-L1 Cells Adipocytes / drug effects Adipocytes / immunology* Animals Anti-Inflammatory Agents / administration & dosage Cell Line Diterpenes, Abietane / administration & dosage* Inflammation / immunology* Inflammation / pathology Inflammation / prevention & control* Ligands Macrophages / drug effects Macrophages / immunology* Mice PPAR alpha / immunology* PPAR gamma / immunology*
IF 2.559
Times Cited 41
Human and Animal Cells