論文 - 詳細
| RRC ID | 43269 |
|---|---|
| 著者 | Kang MS, Hirai S, Goto T, Kuroyanagi K, Lee JY, Uemura T, Ezaki Y, Takahashi N, Kawada T. |
| タイトル | Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Obesity is characterized by an enhanced infiltration of macrophages to adipose tissues, which is closely associated with the low-grade inflammatory state and obesity-related pathologies such as type 2 diabetes and cardiovascular diseases. We showed here that dehydroabietic acid (DAA) is a potent PPARalpha/gamma dual activator. Furthermore, we examined the anti-inflammatory effects of DAA in stimulated macrophages and in the coculture of macrophages and adipocytes. DAA significantly suppressed the production of proinflammatory mediators such as MCP-1, TNF-alpha, and NO in stimulated RAW 264 macrophages and in the coculture of RAW 264 macrophages and 3T3-L1 adipocytes. These results suggest that DAA is a valuable medicinal and food component for improving inflammatory changes associated with obesity-related diabetes. |
| 巻・号 | 369(2) |
| ページ | 333-8 |
| 公開日 | 2008-5-2 |
| DOI | 10.1016/j.bbrc.2008.02.002 |
| PII | S0006-291X(08)00240-4 |
| PMID | 18267111 |
| MeSH | 3T3-L1 Cells Abietanes / administration & dosage* Adipocytes / drug effects Adipocytes / immunology* Animals Anti-Inflammatory Agents / administration & dosage Cell Line Inflammation / immunology* Inflammation / pathology Inflammation / prevention & control* Ligands Macrophages / drug effects Macrophages / immunology* Mice PPAR alpha / immunology* PPAR gamma / immunology* |
| IF | 2.985 |
| 引用数 | 69 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |