| RRC ID |
43309
|
| Author |
Kimura Y, Sumiyoshi M, Baba K.
|
| Title |
Anti-tumor actions of major component 3'-O-acetylhamaudol of Angelica japonica roots through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation.
|
| Journal |
Cancer Lett
|
| Abstract |
We recently demonstrated that two chalcones isolated from Angelica keiskei roots have anti-tumor and anti-metastatic activities through the inhibition of tumor-induced angiogenesis, but the anti-tumor substances of Angelica japonica roots are unknown. We attempted to clarify the anti-tumor action and its mechanisms of a major component 3'-O-acetylhamaudol isolated from A. japonica roots. We first examined the effects of 3'-O-acetylhamaudol on tumor growth in colon 26-bearing mice. Furthermore, we examined the effects of 3'-O-acetylhamaudol on angiogenic factors (vascular endothelial growth factor receptor-2 (VEGFR-2) phosphorylation in human umbilical vein endothelial cells (HUVECs), and vascular endothelial growth factor (VEGF) production and hypoxia-inducible factor (HIF)-1alpha expression in tumors). 3'-O-Acetylhamaudol (25 and 50 mg/kg, twice daily) inhibited the tumor growth in colon 26-bearing mice. Although 3'-O-acetylhamudol had no effect on the VEGF production and HIF-1alpha in colon 26 cells, it (10 microM) inhibited the VEGF-induced angiogenesis and VEGF-induced VEGFR-2 phosphorylation in HUVECs. 3'-O-Acetylhamaudol has anti-tumor effects mediated through dual mechanisms, i.e., anti-angiogenic actions and the modulation of the immune system in the spleen and small intestine in tumor-bearing mice.
|
| Volume |
265(1)
|
| Pages |
84-97
|
| Published |
2008-6-28
|
| DOI |
10.1016/j.canlet.2008.02.009
|
| PII |
S0304-3835(08)00088-8
|
| PMID |
18358599
|
| MeSH |
Angelica / chemistry*
Angiogenesis Inhibitors / pharmacology
Angiogenesis Inhibitors / therapeutic use
Animals
Antineoplastic Agents, Phytogenic / pharmacology*
Antineoplastic Agents, Phytogenic / therapeutic use
Cells, Cultured
Chromones / pharmacology*
Chromones / therapeutic use
Colonic Neoplasms / blood supply
Colonic Neoplasms / drug therapy
Colonic Neoplasms / pathology
Endothelial Cells / drug effects
Endothelial Cells / metabolism
Endothelium, Vascular / cytology
Extracellular Space / metabolism
Humans
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
Intestinal Mucosa / immunology
Intestinal Mucosa / pathology*
Intestine, Small / immunology
Intestine, Small / pathology
Lymphocyte Activation / drug effects*
Male
Mice
Mice, Inbred BALB C
Neoplasm Transplantation
Neovascularization, Pathologic / drug therapy*
Phosphorylation
Plant Roots / chemistry*
Transplantation, Heterologous
Vascular Endothelial Growth Factor Receptor-2 / metabolism
|
| IF |
7.36
|
| Times Cited |
15
|
|
WOS Category
|
ONCOLOGY
|
| Resource |
| Human and Animal Cells |
YAC-1(RCB1165) |
