| RRC ID |
43310
|
| Author |
Satoh T, Arii J, Suenaga T, Wang J, Kogure A, Uehori J, Arase N, Shiratori I, Tanaka S, Kawaguchi Y, Spear PG, Lanier LL, Arase H.
|
| Title |
PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B.
|
| Journal |
Cell
|
| Abstract |
Glycoprotein B (gB) is one of the essential components for infection by herpes simplex virus-1 (HSV-1). Although several cellular receptors that associate with glycoprotein D (gD), such as herpes virus entry mediator (HVEM) and Nectin-1, have been identified, specific molecules that mediate HSV-1 infection by associating with gB have not been elucidated. Here, we found that paired immunoglobulin-like type 2 receptor (PILR) alpha associates with gB, and cells transduced with PILRalpha become susceptible to HSV-1 infection. Furthermore, HSV-1 infection of human primary cells expressing both HVEM and PILRalpha was blocked by either anti-PILRalpha or anti-HVEM antibody. Our results demonstrate that cellular receptors for both gB and gD are required for HSV-1 infection and that PILRalpha plays an important role in HSV-1 infection as a coreceptor that associates with gB. These findings uncover a crucial aspect of the mechanism underlying HSV-1 infection.
|
| Volume |
132(6)
|
| Pages |
935-44
|
| Published |
2008-3-21
|
| DOI |
10.1016/j.cell.2008.01.043
|
| PII |
S0092-8674(08)00205-5
|
| PMID |
18358807
|
| PMC |
PMC2394663
|
| MeSH |
Animals
Antibodies, Monoclonal / metabolism
CHO Cells
Cell Line
Cells, Cultured
Cricetinae
Cricetulus
Herpes Simplex / metabolism*
Herpes Simplex / virology
Herpesvirus 1, Human / metabolism*
Humans
Membrane Glycoproteins / metabolism*
Receptors, Immunologic / metabolism*
Receptors, Virus / metabolism*
Transfection
Viral Envelope Proteins / metabolism*
|
| IF |
38.637
|
| Times Cited |
180
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| Human and Animal Cells |
293T(RCB2202)
COS-7(RCB0539) |
