論文 - 詳細
| RRC ID | 43313 |
|---|---|
| 著者 | Kuramochi K, Yukizawa S, Ikeda S, Sunoki T, Arai S, Matsui R, Morita A, Mizushina Y, Sakaguchi K, Sugawara F, Ikekita M, Kobayashi S. |
| タイトル | Syntheses and applications of fluorescent and biotinylated epolactaene derivatives: Epolactaene and its derivative induce disulfide formation. |
| ジャーナル | Bioorg Med Chem |
| Abstract |
Epolactaene, isolated from cultured Penicillium sp. BM 1689-P mycelium, induces neurite outgrowth and arrests the cell cycle of the human neuroblastoma cell line, SH-SY5Y, at the G1 phase. We have found that epolactaene and its derivatives induce apoptosis in the human leukemia B-cell line, BALL-1. In this study, we prepared fluorescent and biotinylated epolactaene derivatives. We characterized the cellular location and the identification of BALL-1 proteins that reacted with these compounds. The results obtained from the reaction of epolactaene or its derivative with N-acetylcysteine methyl ester indicate that these compounds induce the disulfide formation and the alpha-position of the epoxylactam core is the reactive site. |
| 巻・号 | 16(9) |
| ページ | 5039-49 |
| 公開日 | 2008-5-1 |
| DOI | 10.1016/j.bmc.2008.03.029 |
| PII | S0968-0896(08)00241-1 |
| PMID | 18375133 |
| MeSH | Acetylcysteine / analogs & derivatives Acetylcysteine / chemistry Biotin / chemistry* Biotinylation Cell Death / drug effects Disulfides / chemistry* Drug Screening Assays, Antitumor Epoxy Compounds / chemical synthesis Epoxy Compounds / chemistry Epoxy Compounds / pharmacology Fluorescence Humans Molecular Structure Polyenes / chemical synthesis Polyenes / chemistry Polyenes / pharmacology Stereoisomerism Tumor Cells, Cultured |
| IF | 3.073 |
| 引用数 | 10 |
| WOS 分野 | CHEMISTRY, ORGANIC CHEMISTRY, MEDICINAL BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | BALL-1(RCB0256) |