| RRC ID |
43313
|
| 著者 |
Kuramochi K, Yukizawa S, Ikeda S, Sunoki T, Arai S, Matsui R, Morita A, Mizushina Y, Sakaguchi K, Sugawara F, Ikekita M, Kobayashi S.
|
| タイトル |
Syntheses and applications of fluorescent and biotinylated epolactaene derivatives: Epolactaene and its derivative induce disulfide formation.
|
| ジャーナル |
Bioorg Med Chem
|
| Abstract |
Epolactaene, isolated from cultured Penicillium sp. BM 1689-P mycelium, induces neurite outgrowth and arrests the cell cycle of the human neuroblastoma cell line, SH-SY5Y, at the G1 phase. We have found that epolactaene and its derivatives induce apoptosis in the human leukemia B-cell line, BALL-1. In this study, we prepared fluorescent and biotinylated epolactaene derivatives. We characterized the cellular location and the identification of BALL-1 proteins that reacted with these compounds. The results obtained from the reaction of epolactaene or its derivative with N-acetylcysteine methyl ester indicate that these compounds induce the disulfide formation and the alpha-position of the epoxylactam core is the reactive site.
|
| 巻・号 |
16(9)
|
| ページ |
5039-49
|
| 公開日 |
2008-5-1
|
| DOI |
10.1016/j.bmc.2008.03.029
|
| PII |
S0968-0896(08)00241-1
|
| PMID |
18375133
|
| MeSH |
Acetylcysteine / analogs & derivatives
Acetylcysteine / chemistry
Biotin / chemistry*
Biotinylation
Cell Death / drug effects
Disulfides / chemistry*
Drug Screening Assays, Antitumor
Epoxy Compounds / chemical synthesis
Epoxy Compounds / chemistry
Epoxy Compounds / pharmacology
Fluorescence
Humans
Molecular Structure
Polyenes / chemical synthesis
Polyenes / chemistry
Polyenes / pharmacology
Stereoisomerism
Tumor Cells, Cultured
|
| IF |
3.073
|
| 引用数 |
10
|
|
WOS 分野
|
CHEMISTRY, ORGANIC
CHEMISTRY, MEDICINAL
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
BALL-1(RCB0256) |
