論文 - 詳細
| RRC ID | 43324 |
|---|---|
| 著者 | Wang CY, Miyazaki N, Yamashita T, Higashiura A, Nakagawa A, Li TC, Takeda N, Xing L, Hjalmarsson E, Friberg C, Liou DM, Sung YJ, Tsukihara T, Matsuura Y, Miyamura T, Cheng RH. |
| タイトル | Crystallization and preliminary X-ray diffraction analysis of recombinant hepatitis E virus-like particle. |
| ジャーナル | Acta Crystallogr Sect F Struct Biol Cryst Commun |
| Abstract |
Hepatitis E virus (HEV) accounts for the majority of enterically transmitted hepatitis infections worldwide. Currently, there is no specific treatment for or vaccine against HEV. The major structural protein is derived from open reading frame (ORF) 2 of the viral genome. A potential oral vaccine is provided by the virus-like particles formed by a protein construct of partial ORF3 protein (residue 70-123) fused to the N-terminus of the ORF2 protein (residues 112-608). Single crystals obtained by the hanging-drop vapour-diffusion method at 293 K diffract X-rays to 8.3 A resolution. The crystals belong to space group P2(1)2(1)2(1), with unit-cell parameters a = 337, b = 343, c = 346 A, alpha = beta = gamma = 90 degrees , and contain one particle per asymmetric unit. |
| 巻・号 | 64(Pt 4) |
| ページ | 318-22 |
| 公開日 | 2008-4-1 |
| DOI | 10.1107/S1744309108007197 |
| PII | S1744309108007197 |
| PMID | 18391436 |
| PMC | PMC2374242 |
| MeSH | Capsid Proteins / chemistry Capsid Proteins / genetics Crystallization Hepatitis E virus / chemistry* Hepatitis E virus / genetics Peptide Fragments / chemistry Peptide Fragments / genetics Recombinant Fusion Proteins / analysis Recombinant Fusion Proteins / chemistry* Recombinant Fusion Proteins / genetics Virion / chemistry* Virion / genetics X-Ray Diffraction* |
| IF | 0.968 |
| 引用数 | 13 |
| WOS 分野 | CRYSTALLOGRAPHY BIOPHYSICS BIOCHEMICAL RESEARCH METHODS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| ヒト・動物細胞 | Sf9(RCB0569) |