| RRC ID |
43325
|
| Author |
Ohguchi K, Koike M, Suwa Y, Koshimizu S, Mizutani Y, Nozawa Y, Akao Y.
|
| Title |
Inhibitory effects of whisky congeners on melanogenesis in mouse B16 melanoma cells.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
We examined the effect of whisky congeners, substances other than ethanol in whisky, on melanogenesis in mouse B16 melanoma cells. Treatment with whisky congeners significantly blocked melanogenesis. Our results indicate that the inhibitory effects of whisky congeners on melanogenesis is due to direct inhibition of tyrosinase activity and to suppression of tyrosinase protein levels.
|
| Volume |
72(4)
|
| Pages |
1107-10
|
| Published |
2008-4-1
|
| DOI |
10.1271/bbb.70734
|
| PII |
JST.JSTAGE/bbb/70734
|
| PMID |
18391453
|
| MeSH |
Alcoholic Beverages* / analysis
Animals
Cattle
Cell Line, Tumor
Flavonoids / pharmacology*
Gene Expression Regulation, Neoplastic / drug effects
Melanins / biosynthesis*
Melanoma, Experimental / metabolism*
Mice
Monophenol Monooxygenase / metabolism
Phenols / pharmacology*
Polyphenols
alpha-MSH / pharmacology
|
| IF |
1.516
|
| Times Cited |
8
|
|
WOS Category
|
FOOD SCIENCE & TECHNOLOGY
CHEMISTRY, APPLIED
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
B16 melanoma 4A5(RCB0557) |
