論文 - 詳細
| RRC ID | 43359 |
|---|---|
| 著者 | Kim YJ, Kang KS, Yokozawa T. |
| タイトル | The anti-melanogenic effect of pycnogenol by its anti-oxidative actions. |
| ジャーナル | Food Chem Toxicol |
| Abstract |
Pycnogenol is a natural plant extract from pine bark that contains compounds that have anti-oxidative, free-radical scavenging properties. In this work, utilizing cultured B16 melanoma cells (B16 cells), pycnogenol was investigated for its ability to inhibit tyrosinase activity and melanin biosynthesis. We also examined the anti-oxidative power of pycnogenol by measuring its suppressive effect against peroxynitrite (ONOO-), superoxide (.O2), nitric oxide (NO.), and hydroxyl radical (.OH)-scavenging activities using an electron spin resonance spectrometer. Results show that pycnogenol had a strong anti-tyrosinase activity and suppressed melanin biosynthesis. Further, our results showed that through its anti-oxidative properties, pycnogenol suppressed .O2) NO., ONOO-, and .OH in in vitro assays, and reactive species, ONOO-, .O2, and NO., while up-regulating the reduced glutathione/oxidized glutathione ratio in B16 cells. Based on the findings, we propose that pycnogenol exerts anti-melanogenic activity via its anti-oxidative actions. |
| 巻・号 | 46(7) |
| ページ | 2466-71 |
| 公開日 | 2008-7-1 |
| DOI | 10.1016/j.fct.2008.04.002 |
| PII | S0278-6915(08)00173-7 |
| PMID | 18482785 |
| MeSH | Animals Dose-Response Relationship, Drug Electron Spin Resonance Spectroscopy Enzyme Inhibitors Flavonoids / pharmacology* Free Radical Scavengers / metabolism Hydroxyl Radical / metabolism Melanins / antagonists & inhibitors Melanins / biosynthesis* Melanoma, Experimental / enzymology* Mice Monophenol Monooxygenase / antagonists & inhibitors* Nitric Oxide / metabolism Oxidation-Reduction Oxidative Stress / drug effects* Peptides / pharmacology* Peroxynitrous Acid / metabolism Plant Extracts Superoxides / metabolism Tumor Cells, Cultured |
| IF | 4.679 |
| 引用数 | 70 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY TOXICOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | B16 |