| RRC ID |
43381
|
| Author |
Ha JE, Choi YE, Jang J, Yoon CH, Kim HY, Bae YS.
|
| Title |
FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis.
|
| Journal |
FEBS J
|
| Abstract |
One of the characteristic features of the pathogenesis of rheumatoid arthritis is synovial hyperplasia. We have reported previously that metastatic lymph node 51 (MLN51) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are involved in the proliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis. In this study, we have found that: (1) GM-CSF-mediated MLN51 upregulation is attributable to both transcriptional and post-translational control in rheumatoid arthritis fibroblast-like synoviocytes; (2) p38 mitogen-activated protein kinase plays a key role in the upregulation of MLN51; and (3) FLICE-inhibitory protein is upregulated downstream of MLN51 in response to GM-CSF, resulting in the proliferation of fibroblast-like synoviocytes. These results imply that GM-CSF signaling activates mitogen-activated protein kinase, followed by the upregulation of MLN51 and FLICE-inhibitory protein, resulting in fibroblast-like synoviocyte hyperplasia in rheumatoid arthritis.
|
| Volume |
275(14)
|
| Pages |
3546-55
|
| Published |
2008-7-1
|
| DOI |
10.1111/j.1742-4658.2008.06500.x
|
| PII |
EJB6500
|
| PMID |
18513326
|
| MeSH |
Apoptosis
Arthritis, Rheumatoid / etiology*
Arthritis, Rheumatoid / metabolism
Arthritis, Rheumatoid / pathology
CASP8 and FADD-Like Apoptosis Regulating Protein / biosynthesis
CASP8 and FADD-Like Apoptosis Regulating Protein / physiology*
Cell Line
Cell Proliferation / drug effects
Fibroblasts / cytology
Fibroblasts / drug effects
Fibroblasts / metabolism
Gene Expression Regulation
Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology
Humans
Mitogen-Activated Protein Kinases / physiology*
Neoplasm Proteins / biosynthesis
Neoplasm Proteins / genetics
Neoplasm Proteins / physiology*
Nuclear Proteins / biosynthesis
Nuclear Proteins / genetics
Nuclear Proteins / physiology*
RNA-Binding Proteins
Synovial Membrane / cytology*
Up-Regulation
|
| IF |
4.392
|
| Times Cited |
9
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
MH7A(RCB1512) |
