RRC ID 43381
著者 Ha JE, Choi YE, Jang J, Yoon CH, Kim HY, Bae YS.
タイトル FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis.
ジャーナル FEBS J
Abstract One of the characteristic features of the pathogenesis of rheumatoid arthritis is synovial hyperplasia. We have reported previously that metastatic lymph node 51 (MLN51) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are involved in the proliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis. In this study, we have found that: (1) GM-CSF-mediated MLN51 upregulation is attributable to both transcriptional and post-translational control in rheumatoid arthritis fibroblast-like synoviocytes; (2) p38 mitogen-activated protein kinase plays a key role in the upregulation of MLN51; and (3) FLICE-inhibitory protein is upregulated downstream of MLN51 in response to GM-CSF, resulting in the proliferation of fibroblast-like synoviocytes. These results imply that GM-CSF signaling activates mitogen-activated protein kinase, followed by the upregulation of MLN51 and FLICE-inhibitory protein, resulting in fibroblast-like synoviocyte hyperplasia in rheumatoid arthritis.
巻・号 275(14)
ページ 3546-55
公開日 2008-7-1
DOI 10.1111/j.1742-4658.2008.06500.x
PII EJB6500
PMID 18513326
MeSH Apoptosis Arthritis, Rheumatoid / etiology* Arthritis, Rheumatoid / metabolism Arthritis, Rheumatoid / pathology CASP8 and FADD-Like Apoptosis Regulating Protein / biosynthesis CASP8 and FADD-Like Apoptosis Regulating Protein / physiology* Cell Line Cell Proliferation / drug effects Fibroblasts / cytology Fibroblasts / drug effects Fibroblasts / metabolism Gene Expression Regulation Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology Humans Mitogen-Activated Protein Kinases / physiology* Neoplasm Proteins / biosynthesis Neoplasm Proteins / genetics Neoplasm Proteins / physiology* Nuclear Proteins / biosynthesis Nuclear Proteins / genetics Nuclear Proteins / physiology* RNA-Binding Proteins Synovial Membrane / cytology* Up-Regulation
IF 4.392
引用数 9
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
ヒト・動物細胞 MH7A(RCB151)