論文 - 詳細
| RRC ID | 43381 |
|---|---|
| 著者 | Ha JE, Choi YE, Jang J, Yoon CH, Kim HY, Bae YS. |
| タイトル | FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis. |
| ジャーナル | FEBS J |
| Abstract |
One of the characteristic features of the pathogenesis of rheumatoid arthritis is synovial hyperplasia. We have reported previously that metastatic lymph node 51 (MLN51) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are involved in the proliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis. In this study, we have found that: (1) GM-CSF-mediated MLN51 upregulation is attributable to both transcriptional and post-translational control in rheumatoid arthritis fibroblast-like synoviocytes; (2) p38 mitogen-activated protein kinase plays a key role in the upregulation of MLN51; and (3) FLICE-inhibitory protein is upregulated downstream of MLN51 in response to GM-CSF, resulting in the proliferation of fibroblast-like synoviocytes. These results imply that GM-CSF signaling activates mitogen-activated protein kinase, followed by the upregulation of MLN51 and FLICE-inhibitory protein, resulting in fibroblast-like synoviocyte hyperplasia in rheumatoid arthritis. |
| 巻・号 | 275(14) |
| ページ | 3546-55 |
| 公開日 | 2008-7-1 |
| DOI | 10.1111/j.1742-4658.2008.06500.x |
| PII | EJB6500 |
| PMID | 18513326 |
| MeSH | Apoptosis Arthritis, Rheumatoid / etiology* Arthritis, Rheumatoid / metabolism Arthritis, Rheumatoid / pathology CASP8 and FADD-Like Apoptosis Regulating Protein / biosynthesis CASP8 and FADD-Like Apoptosis Regulating Protein / physiology* Cell Line Cell Proliferation / drug effects Fibroblasts / cytology Fibroblasts / drug effects Fibroblasts / metabolism Gene Expression Regulation Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology Humans Mitogen-Activated Protein Kinases / physiology* Neoplasm Proteins / biosynthesis Neoplasm Proteins / genetics Neoplasm Proteins / physiology* Nuclear Proteins / biosynthesis Nuclear Proteins / genetics Nuclear Proteins / physiology* RNA-Binding Proteins Synovial Membrane / cytology* Up-Regulation |
| IF | 4.392 |
| 引用数 | 9 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | MH7A(RCB1512) |