論文 - 詳細
RRC ID | 43468 |
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著者 | Ishiguro K, Ando T, Watanabe O, Goto H. |
タイトル | Specific reaction of alpha,beta-unsaturated carbonyl compounds such as 6-shogaol with sulfhydryl groups in tubulin leading to microtubule damage. |
ジャーナル | FEBS Lett |
Abstract |
6-Shogaol and 6-gingerol are ginger components with similar chemical structures. However, while 6-shogaol damages microtubules, 6-gingerol does not. We have investigated the molecular mechanism of 6-shogaol-induced microtubule damage and found that the action of 6-shogaol results from the structure of alpha,beta-unsaturated carbonyl compounds. alpha,beta-Unsaturated carbonyl compounds such as 6-shogaol react with sulfhydryl groups of cysteine residues in tubulin, and impair tubulin polymerization. The reaction with sulfhydryl groups depends on the chain length of alpha,beta-unsaturated carbonyl compounds. In addition, alpha,beta-unsaturated carbonyl compounds are more reactive with sulfhydryl groups in tubulin than in 2-mercaptoethanol, dithiothreitol, glutathione and papain, a cysteine protease. |
巻・号 | 582(23-24) |
ページ | 3531-6 |
公開日 | 2008-10-15 |
DOI | 10.1016/j.febslet.2008.09.027 |
PII | S0014-5793(08)00762-X |
PMID | 18805415 |
MeSH | Catechols / chemistry Catechols / metabolism* Catechols / pharmacology Cell Line Cell Line, Tumor Cysteine / chemistry Cysteine / metabolism* Fatty Alcohols / chemistry Fatty Alcohols / metabolism Fatty Alcohols / pharmacology Humans Microtubules / drug effects* Microtubules / metabolism Molecular Structure Tubulin / metabolism* |
IF | 3.057 |
引用数 | 25 |
WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
リソース情報 | |
ヒト・動物細胞 |