| RRC ID |
43531
|
| 著者 |
Hanamura T, Uchida E, Aoki H.
|
| タイトル |
Skin-lightening effect of a polyphenol extract from Acerola (Malpighia emarginata DC.) fruit on UV-induced pigmentation.
|
| ジャーナル |
Biosci Biotechnol Biochem
|
| Abstract |
To investigate the physiological functions of polyphenols from acerola (Malpighia emarginata DC.) fruit, the effects on melanogenesis were studied. The crude polyphenol concentrated extract from acerola (C-AP) was used to examine the skin-lightening effect on brownish guinea pigs which had been subjected to controlled UVB irradiation. The results show that C-AP significantly lightened the UVB-irradiated skin pigmentation. Furthermore, treatment with C-AP reduced the content of melanin in B16 melanoma cells, suggesting that the in vivo skin-lightening effect of C-AP was due to the suppression of melanin biosynthesis in melanocytes. In addition, we found that C-AP could effectively inhibit mushroom tyrosinase activity, the main constituents responsible for this effect being thought to be such anthocyanins as cyanidin-3-alpha-O-rhamnoside (C3R) and pelargonidin-3-alpha-O-rhamnoside (P3R). This result indicates that the skin-lightening effect of C-AP can be partly attributed to the suppression of melanogenesis through the inhibition of tyrosinase activity in melanocytes. An oral ingestion of C-AP may therefore be efficacious for reducing UVB-induced hyper-pigmentation by inhibiting the tyrosinase in melanocytes.
|
| 巻・号 |
72(12)
|
| ページ |
3211-8
|
| 公開日 |
2008-12-1
|
| DOI |
10.1271/bbb.80421
|
| PII |
JST.JSTAGE/bbb/80421
|
| PMID |
19060403
|
| MeSH |
Administration, Oral
Agaricales / enzymology
Animals
Cell Line, Tumor
Epidermis / drug effects
Epidermis / metabolism
Epidermis / radiation effects
Female
Flavonoids / chemistry*
Fruit / chemistry*
Guinea Pigs
Magnoliopsida / chemistry*
Melanins / metabolism
Melanosomes / drug effects
Melanosomes / metabolism
Melanosomes / radiation effects
Mice
Monophenol Monooxygenase / antagonists & inhibitors
Phenols / chemistry*
Plant Extracts / administration & dosage
Plant Extracts / pharmacology*
Polyphenols
Skin / cytology
Skin / drug effects*
Skin / metabolism
Skin / radiation effects
Skin Pigmentation / drug effects*
Skin Pigmentation / radiation effects
Ultraviolet Rays* / adverse effects
|
| IF |
1.516
|
| 引用数 |
35
|
|
WOS 分野
|
FOOD SCIENCE & TECHNOLOGY
CHEMISTRY, APPLIED
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
B16 melanoma 4A5(RCB0557) |
