論文 - 詳細
| RRC ID | 43531 |
|---|---|
| 著者 | Hanamura T, Uchida E, Aoki H. |
| タイトル | Skin-lightening effect of a polyphenol extract from Acerola (Malpighia emarginata DC.) fruit on UV-induced pigmentation. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
To investigate the physiological functions of polyphenols from acerola (Malpighia emarginata DC.) fruit, the effects on melanogenesis were studied. The crude polyphenol concentrated extract from acerola (C-AP) was used to examine the skin-lightening effect on brownish guinea pigs which had been subjected to controlled UVB irradiation. The results show that C-AP significantly lightened the UVB-irradiated skin pigmentation. Furthermore, treatment with C-AP reduced the content of melanin in B16 melanoma cells, suggesting that the in vivo skin-lightening effect of C-AP was due to the suppression of melanin biosynthesis in melanocytes. In addition, we found that C-AP could effectively inhibit mushroom tyrosinase activity, the main constituents responsible for this effect being thought to be such anthocyanins as cyanidin-3-alpha-O-rhamnoside (C3R) and pelargonidin-3-alpha-O-rhamnoside (P3R). This result indicates that the skin-lightening effect of C-AP can be partly attributed to the suppression of melanogenesis through the inhibition of tyrosinase activity in melanocytes. An oral ingestion of C-AP may therefore be efficacious for reducing UVB-induced hyper-pigmentation by inhibiting the tyrosinase in melanocytes. |
| 巻・号 | 72(12) |
| ページ | 3211-8 |
| 公開日 | 2008-12-1 |
| DOI | 10.1271/bbb.80421 |
| PII | JST.JSTAGE/bbb/80421 |
| PMID | 19060403 |
| MeSH | Administration, Oral Agaricales / enzymology Animals Cell Line, Tumor Epidermis / drug effects Epidermis / metabolism Epidermis / radiation effects Female Flavonoids / chemistry* Fruit / chemistry* Guinea Pigs Magnoliopsida / chemistry* Melanins / metabolism Melanosomes / drug effects Melanosomes / metabolism Melanosomes / radiation effects Mice Monophenol Monooxygenase / antagonists & inhibitors Phenols / chemistry* Plant Extracts / administration & dosage Plant Extracts / pharmacology* Polyphenols Skin / cytology Skin / drug effects* Skin / metabolism Skin / radiation effects Skin Pigmentation / drug effects* Skin Pigmentation / radiation effects Ultraviolet Rays* / adverse effects |
| IF | 1.516 |
| 引用数 | 35 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | B16 melanoma 4A5(RCB0557) |