RRC ID 4359
Author Mochizuki N, Takagi N, Kurokawa K, Onozato C, Moriyama Y, Tanonaka K, Takeo S.
Title Injection of neural progenitor cells improved learning and memory dysfunction after cerebral ischemia.
Journal Exp. Neurol.
Abstract Accumulating evidence indicates that stem cells have the ability to improve neurological deficits seen after cerebral ischemia. However, the effects of neural progenitor cells (NPCs) on cerebral ischemia-induced learning and memory dysfunction remain to be clarified. The purpose of the present study was to determine whether the injection of exogenous NPCs could prevent learning and memory dysfunction after cerebral ischemia. Sustained cerebral ischemia was produced by the injection of 700 microspheres into the right hemisphere of each rat. We demonstrated that injection of NPCs into the hippocampus at 10 min after the induction of cerebral ischemia reduced prolongation of the escape latency seen in acquisition and retention tests of the water maze task on Days 12-28 after cerebral ischemia. Injection of NPCs partially attenuated the decrease in viable areas of the ipsilateral hemisphere on Day 28 after the cerebral ischemia. We also demonstrated that injection of NPCs prevented the decrease in the level of BDNF seen at the early period after cerebral ischemia. These results suggest that the injection of exogenous NPCs into the hippocampus can prevent cerebral ischemia-induced learning and memory dysfunction, possibly through maintenance of the BDNF level.
Volume 211(1)
Pages 194-202
Published 2008-5
DOI 10.1016/j.expneurol.2008.01.027
PII S0014-4886(08)00052-6
PMID 18346733
MeSH Analysis of Variance Animals Behavior, Animal / physiology Brain-Derived Neurotrophic Factor / metabolism Cerebral Infarction / complications Disease Models, Animal Gene Expression Regulation / physiology Green Fluorescent Proteins / metabolism Learning Disorders / etiology Learning Disorders / therapy* Male Maze Learning / physiology Memory Disorders / etiology Memory Disorders / therapy* Nerve Tissue Proteins / metabolism Neurons / physiology* Rats Rats, Wistar Stem Cell Transplantation / methods* Stem Cells / physiology* Time Factors
IF 4.483
Times Cited 24
WOS Category NEUROSCIENCES
Resource
Rats W-Tg(CAG-GFP)184Ys(strainID=525)