RRC ID 4362
Author Kuramoto T, Nakanishi S, Serikawa T.
Title Functional polymorphisms in inbred rat strains and their allele frequencies in commercially available outbred stocks.
Journal Physiol. Genomics
Abstract Polymorphisms that have been proven to influence gene functions are called functional polymorphisms. It is significant to know the distribution of functional polymorphisms in the rat, widely used in animal models for human diseases. In this study, we assessed 16 functional polymorphisms consisting of 3 coat color and 13 disease-associated genes in 136 rat strains, as a part of the genetic profiling program of the National Bio Resource Project for the Rat (NBRP-Rat). Polymorphisms of Cdkn1a, Fcgr3, Grp10, Lss, and Fdft1, which were proven to function in prostate tumorigenesis, glomerulonephritis, hyperphagia, and cholesterol biosynthesis, were shared among various inbred strains. These findings indicated that most rat strains harbored the disease-associated alleles and suggested that many unidentified functional polymorphisms might exist in inbred rat strains. The functional polymorphisms shared in inbred strains were also observed within outbred stocks available commercially. Therefore, this implies that experimental plans based on either rat inbred strains or outbred stocks need to be carefully designed with a full understanding of the genetic characteristics of the animals. To select the most suitable strains for experiments, the NBRP-Rat will periodically improve and update the genetic profiles of rat strains.
Volume 33(2)
Pages 205-11
Published 2008-4-22
DOI 10.1152/physiolgenomics.00222.2007
PII 00222.2007
PMID 18212005
MeSH Animals Animals, Outbred Strains Color Disease* Gene Frequency* Genotype Mutation Polymorphism, Genetic* Rats Rats, Inbred Strains
IF 2.581
Times Cited 5
WOS Category GENETICS & HEREDITY PHYSIOLOGY CELL BIOLOGY
Resource
Rats ACI/NHok(strainID=62) ACI/NKyo(strainID=6) ACI-Lystbg-Kyo/Kyo(strainID=7) ACI/NMna(strainID=461) ACI/NSlc(strainID=381) ACIS/Hok(strainID=63) AI/Msik(strainID=443) ALB/Hok(strainID=64) BB/WorTky(strainID=30) BN/1Hok(strainID=66) BN/2Hok(strainID=67) BN/fKtsSlc(strainID=388) BN/fMaiHok(strainID=65) BN/KunKtsSlc(strainID=387) BN/SsNSlc(strainID=371) BUF/Mna(strainID=458) DA/Slc(strainID=380) DMY/Kyo(strainID=8) DON/Kyo(strainID=1) DOP/Nem(strainID=151) DRH/Seac(strainID=111) F344/NSlc(strainID=379) F344.Cg-Foxn1rnu/Kyo(strainID=541) F344/Stm(strainID=266) FH/HamSlc(strainID=384) GAERS/Mave(strainID=557) GK/Slc(strainID=377) GRY/Kyo(strainID=498) Gunn-Ugt1a1j/Slc(strainID=370) HAA/FDSC(strainID=496) HOB/Snk(strainID=154) HTX/Kyo(strainID=3) HWY/Slc(strainID=374) ICR/Ihr(strainID=731) IER/Ihr(strainID=732) IEW/Ihr(strainID=733) IS/Kyo(strainID=5) IS-Tlk/Kyo(strainID=25) KB/Oda(strainID=581) KDP/Tky(strainID=15) KHR/Kyo(strainID=4) KMI/Tky(strainID=29) KND/Tky(strainID=16) KYN/Hok(strainID=69) KZC/Tky(strainID=20) KZ-Leprfa/Tky(strainID=32) LAA/FDSC(strainID=497) LE/Stm(strainID=265) LEA/Hkm(strainID=495) LEA/Hok(strainID=70) LEA/Tj(strainID=79) LEC/Hok(strainID=71) LEJ/Hkm(strainID=494) LEJ/Hok(strainID=72) LEW/Jms(strainID=192) LEW/SsNSlc(strainID=372) MD/Tama(strainID=248) MES/Slc(strainID=383) NAR/Slc(strainID=375) NE/Mave(strainID=558) NER/Kyo(strainID=26) NIG-III/Hok(strainID=73) OM/NSlc(strainID=385) OP/Jtt(strainID=181) PVG/Seac(strainID=113) RCS/Kyo(strainID=27) SD-Tg(CAG-Rgn)Slc(strainID=389) RICO/Ngs(strainID=479) SDJ/Hok(strainID=74) SER/Kyo(strainID=28) SHR/Hcm(strainID=441) SHR/Izm(strainID=411) SHR/Kyo(strainID=9) SHR/Nig(strainID=286) SHR/Ta(strainID=418) SHR/2Dmcr(strainID=564) SHR/3Dmcr(strainID=565) SHR/4Dmcr(strainID=566) SHRSP/Izm(strainID=409) SHRSP/Ngsk(strainID=303) SHRSP/Ta(strainID=414) SHRSP/2Ta(strainID=417) SHRSP/3Dmcr(strainID=567) SHRSR/Ta(strainID=416) THE/Utp(strainID=516) TLE/Utp(strainID=515) TM/Kyo(strainID=10) TO/Hok(strainID=75) TO/Hkm(strainID=493) TRM/Kyo(strainID=11) TRMR/Kyo(strainID=12) UPL/Cas(strainID=472) VF/Kyo(strainID=21) W/Kyo(strainID=13) WAG/RijKyo(strainID=14) WBN/KobSlc(strainID=378) WF/Kop(strainID=510) WIAR/Iar(strainID=536) WKA/Seac(strainID=112) WKAH/HkmSlc(strainID=376) WKAH/Hok(strainID=76) WKY/Ezo(strainID=568) WKY/Hcm(strainID=442) WKY/Izm(strainID=412) WKY/NMna(strainID=460) WKY/Ta(strainID=419) WKYO/Kyo(strainID=17) WNA/Num(strainID=149) WT/Jtt(strainID=476) WTC/Kyo(strainID=18) ZI/Kyo(strainID=23) ZIMY/Kyo(strainID=24)