RRC ID 43623
Author Poulose AC, Veeranarayanan S, Mohamed MS, Raveendran S, Nagaoka Y, Yoshida Y, Maekawa T, Kumar DS.
Title PEG coated biocompatible cadmium chalcogenide quantum dots for targeted imaging of cancer cells.
Journal J Fluoresc
Abstract Cancer stands as a leading cause of mortality worldwide and diagnostics of cancer still faces drawbacks. Optical imaging of cancer would allow early diagnosis, evaluation of disease progression and therapy efficiency. To that aim, we have developed highly biocompatible PEG functionalized cadmium chalcogenide based three differently luminescent quantum dots (QDs) (CdS, CdSe and CdTe). Folate targeting scheme was utilized for targeting cancer cell line, MCF-7. We demonstrate the biocompatibility, specificity and efficiency of our nanotool in detection of cancer cells sparing normal cell lines with retained fluorescence of functionalized QDs as parental counterpart. This is the first time report of utilizing three differently fluorescent QDs and we have detailed about the internalization of these materials and time dependent saturation of targeting schemes. We present here the success of utilizing our biocompatible imaging tool for early diagnosis of cancer.
Volume 22(3)
Pages 931-44
Published 2012-5
DOI 10.1007/s10895-011-1032-y
PMID 22227700
MeSH Cadmium / chemistry* Cell Proliferation Chalcogens / chemistry* Coated Materials, Biocompatible / analysis* Coated Materials, Biocompatible / chemical synthesis Coated Materials, Biocompatible / chemistry Humans Luminescent Agents / analysis* Luminescent Agents / chemical synthesis Luminescent Agents / chemistry Molecular Imaging / methods* Neoplasms / diagnosis* Neoplasms / pathology Particle Size Polyethylene Glycols / chemistry* Quantum Dots* Surface Properties Tumor Cells, Cultured
IF 1.913
Times Cited 16
Human and Animal Cells