論文 - 詳細
| RRC ID | 43626 |
|---|---|
| 著者 | Takasao N, Tsuji-Naito K, Ishikura S, Tamura A, Akagawa M. |
| タイトル | Cinnamon extract promotes type I collagen biosynthesis via activation of IGF-I signaling in human dermal fibroblasts. |
| ジャーナル | J Agric Food Chem |
| Abstract |
The breakdown of collagenous networks with aging results in hypoactive changes in the skin. Accordingly, reviving stagnant collagen synthesis can help protect dermal homeostasis against aging. We searched for type I collagen biosynthesis-inducing substances in various foods using human dermal fibroblasts and found that cinnamon extract facilitates collagen biosynthesis. Cinnamon extract potently up-regulated both mRNA and protein expression levels of type I collagen without cytotoxicity. We identified cinnamaldehyde as a major active component promoting the expression of collagen by HPLC and NMR analysis. Since insulin-like growth factor-I (IGF-I) is the most potent stimulator of collagen biosynthesis in fibroblasts, we examined the effect of cinnamaldehyde on IGF-I signaling. Treatment with cinnamaldehyde significantly increased the phosphorylation levels of the IGF-I receptor and its downstream signaling molecules such as insulin receptor substrate-1 and Erk1/2 in an IGF-I-independent manner. These results suggested that cinnamon extract is useful in antiaging treatment of skin. |
| 巻・号 | 60(5) |
| ページ | 1193-200 |
| 公開日 | 2012-2-8 |
| DOI | 10.1021/jf2043357 |
| PMID | 22233457 |
| MeSH | Cell Line Cinnamomum zeylanicum / chemistry* Collagen Type I / biosynthesis* Collagen Type I / genetics Fibroblasts / drug effects* Fibroblasts / metabolism Humans Insulin-Like Growth Factor I / metabolism* Plant Extracts / isolation & purification Plant Extracts / pharmacology* Signal Transduction / drug effects* Skin / cytology* Skin / metabolism |
| IF | 4.192 |
| 引用数 | 30 |
| WOS 分野 | AGRICULTURE, MULTIDISCIPLINARY FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED |
| リソース情報 | |
| ヒト・動物細胞 | NB1RGB(RCB0222) |