RRC ID 43627
著者 Tanaka K, Shirotsuki S, Iwata T, Kageyama C, Tahara T, Nozaki S, Siwu ER, Tamura S, Douke S, Murakami N, Onoe H, Watanabe Y, Fukase K.
タイトル Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 domain.
ジャーナル ACS Chem Biol
Abstract A new synthetic strategy for obtaining artificial receptors that selectively regulate and/or control specific protein/protein interactions was developed based on the template-assisted and the self-activating click reaction applied to a combinatorial library. Synthetic mimics of the Grb2-SH2 domain, examined as a model case, selectively bound to a target signaling protein to induce cytotoxicity and inhibit tumor growth in vivo.
巻・号 7(4)
ページ 637-45
公開日 2012-4-20
DOI 10.1021/cb2003175
PMID 22239652
MeSH Antineoplastic Agents / chemical synthesis Click Chemistry / methods* Combinatorial Chemistry Techniques GRB2 Adaptor Protein Humans Molecular Mimicry* Peptides / chemical synthesis* src Homology Domains*
IF 4.434
引用数 5
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
ヒト・動物細胞