Reference - Detail
|Author||Tanaka K, Shirotsuki S, Iwata T, Kageyama C, Tahara T, Nozaki S, Siwu ER, Tamura S, Douke S, Murakami N, Onoe H, Watanabe Y, Fukase K.|
|Title||Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 domain.|
|Journal||ACS Chem Biol|
A new synthetic strategy for obtaining artificial receptors that selectively regulate and/or control specific protein/protein interactions was developed based on the template-assisted and the self-activating click reaction applied to a combinatorial library. Synthetic mimics of the Grb2-SH2 domain, examined as a model case, selectively bound to a target signaling protein to induce cytotoxicity and inhibit tumor growth in vivo.
|MeSH||Antineoplastic Agents / chemical synthesis Click Chemistry / methods* Combinatorial Chemistry Techniques GRB2 Adaptor Protein Humans Molecular Mimicry* Peptides / chemical synthesis* src Homology Domains*|
|WOS Category||BIOCHEMISTRY & MOLECULAR BIOLOGY|
|Human and Animal Cells|