RRC ID 43627
Author Tanaka K, Shirotsuki S, Iwata T, Kageyama C, Tahara T, Nozaki S, Siwu ER, Tamura S, Douke S, Murakami N, Onoe H, Watanabe Y, Fukase K.
Title Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 domain.
Journal ACS Chem Biol
Abstract A new synthetic strategy for obtaining artificial receptors that selectively regulate and/or control specific protein/protein interactions was developed based on the template-assisted and the self-activating click reaction applied to a combinatorial library. Synthetic mimics of the Grb2-SH2 domain, examined as a model case, selectively bound to a target signaling protein to induce cytotoxicity and inhibit tumor growth in vivo.
Volume 7(4)
Pages 637-45
Published 2012-4-20
DOI 10.1021/cb2003175
PMID 22239652
MeSH Antineoplastic Agents / chemical synthesis Click Chemistry / methods* Combinatorial Chemistry Techniques GRB2 Adaptor Protein Humans Molecular Mimicry* Peptides / chemical synthesis* src Homology Domains*
IF 4.374
Times Cited 5
Human and Animal Cells