論文 - 詳細
| RRC ID | 43627 |
|---|---|
| 著者 | Tanaka K, Shirotsuki S, Iwata T, Kageyama C, Tahara T, Nozaki S, Siwu ER, Tamura S, Douke S, Murakami N, Onoe H, Watanabe Y, Fukase K. |
| タイトル | Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 domain. |
| ジャーナル | ACS Chem Biol |
| Abstract |
A new synthetic strategy for obtaining artificial receptors that selectively regulate and/or control specific protein/protein interactions was developed based on the template-assisted and the self-activating click reaction applied to a combinatorial library. Synthetic mimics of the Grb2-SH2 domain, examined as a model case, selectively bound to a target signaling protein to induce cytotoxicity and inhibit tumor growth in vivo. |
| 巻・号 | 7(4) |
| ページ | 637-45 |
| 公開日 | 2012-4-20 |
| DOI | 10.1021/cb2003175 |
| PMID | 22239652 |
| MeSH | Antineoplastic Agents / chemical synthesis Click Chemistry / methods* Combinatorial Chemistry Techniques GRB2 Adaptor Protein Humans Molecular Mimicry* Peptides / chemical synthesis* src Homology Domains* |
| IF | 4.434 |
| 引用数 | 5 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | |