Reference - Detail
| RRC ID | 43627 |
|---|---|
| Author | Tanaka K, Shirotsuki S, Iwata T, Kageyama C, Tahara T, Nozaki S, Siwu ER, Tamura S, Douke S, Murakami N, Onoe H, Watanabe Y, Fukase K. |
| Title | Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 domain. |
| Journal | ACS Chem Biol |
| Abstract |
A new synthetic strategy for obtaining artificial receptors that selectively regulate and/or control specific protein/protein interactions was developed based on the template-assisted and the self-activating click reaction applied to a combinatorial library. Synthetic mimics of the Grb2-SH2 domain, examined as a model case, selectively bound to a target signaling protein to induce cytotoxicity and inhibit tumor growth in vivo. |
| Volume | 7(4) |
| Pages | 637-45 |
| Published | 2012-4-20 |
| DOI | 10.1021/cb2003175 |
| PMID | 22239652 |
| MeSH | Antineoplastic Agents / chemical synthesis Click Chemistry / methods* Combinatorial Chemistry Techniques GRB2 Adaptor Protein Humans Molecular Mimicry* Peptides / chemical synthesis* src Homology Domains* |
| IF | 4.434 |
| Times Cited | 5 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Resource | |
| Human and Animal Cells | |