論文 - 詳細
RRC ID | 43627 |
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著者 | Tanaka K, Shirotsuki S, Iwata T, Kageyama C, Tahara T, Nozaki S, Siwu ER, Tamura S, Douke S, Murakami N, Onoe H, Watanabe Y, Fukase K. |
タイトル | Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 domain. |
ジャーナル | ACS Chem Biol |
Abstract |
A new synthetic strategy for obtaining artificial receptors that selectively regulate and/or control specific protein/protein interactions was developed based on the template-assisted and the self-activating click reaction applied to a combinatorial library. Synthetic mimics of the Grb2-SH2 domain, examined as a model case, selectively bound to a target signaling protein to induce cytotoxicity and inhibit tumor growth in vivo. |
巻・号 | 7(4) |
ページ | 637-45 |
公開日 | 2012-4-20 |
DOI | 10.1021/cb2003175 |
PMID | 22239652 |
MeSH | Antineoplastic Agents / chemical synthesis Click Chemistry / methods* Combinatorial Chemistry Techniques GRB2 Adaptor Protein Humans Molecular Mimicry* Peptides / chemical synthesis* src Homology Domains* |
IF | 4.434 |
引用数 | 5 |
WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
リソース情報 | |
ヒト・動物細胞 |