Reference - Detail
| RRC ID | 43628 |
|---|---|
| Author | Komizu Y, Ueoka H, Ueoka R. |
| Title | Selective accumulation and growth inhibition of hybrid liposomes to human hepatocellular carcinoma cells in relation to fluidity of plasma membranes. |
| Journal | Biochem Biophys Res Commun |
| Abstract |
Hybrid liposomes (HLs), composed of l-α-dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene(23) dodecyl ether, have selectively inhibited the growth of human hepatocellular carcinoma (HCC) cells without affecting normal hepatocytes to trigger apoptosis via caspase-3 activation. Furthermore, HLs distinguished between the HCC and normal cells which had higher and lower membrane fluidities respectively, then fused and accumulated preferentially into the membranes of HCC cells. It is noteworthy that the anti-cancer activity of HLs correlated well with the fluidity of cell membranes for HCC and other cancer cells. These results suggest that HLs could target cancer cell-membranes in relation to their lipid fluidity that provide the possibility of novel nanotherapy for intractable cancer. |
| Volume | 418(1) |
| Pages | 81-6 |
| Published | 2012-2-3 |
| DOI | 10.1016/j.bbrc.2011.12.134 |
| PII | S0006-291X(11)02343-6 |
| PMID | 22240027 |
| MeSH | Antineoplastic Agents / chemistry* Antineoplastic Agents / metabolism Antineoplastic Agents / pharmacology* Apoptosis / drug effects Carcinoma, Hepatocellular / metabolism* Carcinoma, Hepatocellular / pathology Caspase 3 / metabolism Cell Line, Tumor Cell Membrane / metabolism Cell Membrane / physiology Cell Proliferation / drug effects* Dimyristoylphosphatidylcholine / chemistry* Humans Liposomes / chemistry* Liposomes / metabolism Liposomes / pharmacology* Liver Neoplasms / metabolism* Liver Neoplasms / pathology Membrane Fluidity Nanoparticles Polyethylene Glycols / chemistry* |
| IF | 2.985 |
| Times Cited | 14 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Resource | |
| Human and Animal Cells | HuH-7 Hep G2 |