RRC ID |
43631
|
著者 |
Nagasaki H, Kondo T, Fuchigami M, Hashimoto H, Sugimura Y, Ozaki N, Arima H, Ota A, Oiso Y, Hamada Y.
|
タイトル |
Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor: TNFα enhances GPR84 expression in adipocytes.
|
ジャーナル |
FEBS Lett
|
Abstract |
In this study we aimed to identify the physiological roles of G protein-coupled receptor 84 (GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFα from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity.
|
巻・号 |
586(4)
|
ページ |
368-72
|
公開日 |
2012-2-17
|
DOI |
10.1016/j.febslet.2012.01.001
|
PII |
S0014-5793(12)00014-2
|
PMID |
22245676
|
MeSH |
3T3-L1 Cells
Adipocytes / drug effects
Adipocytes / metabolism
Adiponectin / genetics
Adipose Tissue / metabolism*
Animals
Cell Line
Coculture Techniques
Decanoic Acids / pharmacology
Fatty Acids / metabolism
Gene Expression / drug effects
Inflammation / genetics*
Inflammation / metabolism
Ligands
Macrophages / metabolism
Male
Mice
Mice, Inbred C57BL
RNA, Messenger / genetics
RNA, Messenger / metabolism
Receptors, G-Protein-Coupled / genetics*
Receptors, G-Protein-Coupled / metabolism
Tumor Necrosis Factor-alpha / pharmacology*
|
IF |
3.057
|
引用数 |
47
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
リソース情報 |
ヒト・動物細胞 |
RAW 264(RCB0535) |