RRC ID 43631
著者 Nagasaki H, Kondo T, Fuchigami M, Hashimoto H, Sugimura Y, Ozaki N, Arima H, Ota A, Oiso Y, Hamada Y.
タイトル Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor: TNFα enhances GPR84 expression in adipocytes.
ジャーナル FEBS Lett
Abstract In this study we aimed to identify the physiological roles of G protein-coupled receptor 84 (GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFα from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity.
巻・号 586(4)
ページ 368-72
公開日 2012-2-17
DOI 10.1016/j.febslet.2012.01.001
PII S0014-5793(12)00014-2
PMID 22245676
MeSH 3T3-L1 Cells Adipocytes / drug effects Adipocytes / metabolism Adiponectin / genetics Adipose Tissue / metabolism* Animals Cell Line Coculture Techniques Decanoic Acids / pharmacology Fatty Acids / metabolism Gene Expression / drug effects Inflammation / genetics* Inflammation / metabolism Ligands Macrophages / metabolism Male Mice Mice, Inbred C57BL RNA, Messenger / genetics RNA, Messenger / metabolism Receptors, G-Protein-Coupled / genetics* Receptors, G-Protein-Coupled / metabolism Tumor Necrosis Factor-alpha / pharmacology*
IF 3.057
引用数 47
WOS 分野 BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
ヒト・動物細胞 RAW 264(RCB0535)