| RRC ID |
4369
|
| 著者 |
Tanaka K, Shirakawa H, Okada K, Konno M, Nakagawa T, Serikawa T, Kaneko S.
|
| タイトル |
Increased Ca2+ channel currents in cerebellar Purkinje cells of the ataxic groggy rat.
|
| ジャーナル |
Neurosci Lett
|
| Abstract |
The ataxic groggy rat (strain name; GRY) is an autosomal recessive neurological mutant found in a closed colony of Slc:Wistar rats. Recent genetic analysis has identified the missense (M251K) mutation in the alpha(1) subunit of the Ca(V)2.1 (P/Q-type) voltage-dependent Ca(2+) channel gene (Cacna1a) of GRY rat. In this study, we found that high-voltage-activated (HVA) Ca(2+) channel currents in acutely dissociated Purkinje cells of GRY rats showed increased (not decreased) current density and depolarizing shift of the activation and inactivation curves compared with those of normal Wistar rats. In contrast low-voltage-activated (LVA) Ca(2+) channel currents of GRY rats showed no significant changes. These results suggest that functional alteration of Ca(2+) channel currents in cerebellar Purkinje cells of GRY rats is attributed to the change of HVA Ca(2+) channel currents, and that increased HVA Ca(2+) channel function underlies the cerebellar dysfunction and ataxic phenotype of GRY rats.
|
| 巻・号 |
426(2)
|
| ページ |
75-80
|
| 公開日 |
2007-10-16
|
| DOI |
10.1016/j.neulet.2007.08.046
|
| PII |
S0304-3940(07)00934-2
|
| PMID |
17884288
|
| MeSH |
Animals
Animals, Newborn
Calcium Channels, N-Type / physiology*
Cerebellar Ataxia / genetics
Cerebellar Ataxia / pathology*
Cerebellum / pathology*
Dose-Response Relationship, Radiation
Electric Stimulation / methods
Membrane Potentials / drug effects
Membrane Potentials / genetics
Membrane Potentials / physiology*
Patch-Clamp Techniques / methods
Purkinje Cells / physiology*
Rats
Rats, Wistar
|
| IF |
2.274
|
| 引用数 |
2
|
|
WOS 分野
|
NEUROSCIENCES
|
| リソース情報 |
| ラット |
GRY/Idr(strainID=498) |
