| RRC ID |
43776
|
| 著者 |
Lee JS, Cha HD, Shim JH, Jung JW, Kim JY, Cho DW.
|
| タイトル |
Effect of pore architecture and stacking direction on mechanical properties of solid freeform fabrication-based scaffold for bone tissue engineering.
|
| ジャーナル |
J Biomed Mater Res A
|
| Abstract |
Fabrication of a three-dimensional (3D) scaffold with increased mechanical strength may be an essential requirement for more advanced bone tissue engineering scaffolds. Various material- and chemical-based approaches have been explored to enhance the mechanical properties of engineered bone tissue scaffolds. In this study, the effects of pore architecture and stacking direction on the mechanical and cell proliferation properties of a scaffold were investigated. The 3D scaffold was prepared using solid freeform fabrication technology with a multihead deposition system. Various types of scaffolds with different pore architectures (lattice, stagger, and triangle types) and stacking directions (horizontal and vertical directions) were fabricated with a blend of polycaprolactone and poly lactic-co-glycolic acid. In compression tests, the triangle-type scaffold was the strongest among the experimental groups. Stacking direction affected the mechanical properties of scaffolds. An in vitro cell counting kit-8 assay showed no significant differences in optical density depending on the different pore architectures and stacking directions. In conclusion, mechanical properties of scaffolds can be enhanced by controlling pore architecture and stacking direction.
|
| 巻・号 |
100(7)
|
| ページ |
1846-53
|
| 公開日 |
2012-7-1
|
| DOI |
10.1002/jbm.a.34149
|
| PMID |
22488723
|
| MeSH |
3T3 Cells
Animals
Bone and Bones*
Cell Adhesion
Cell Proliferation
Mice
Microscopy, Electron, Scanning
Tissue Engineering*
Tissue Scaffolds*
|
| IF |
3.525
|
| 引用数 |
54
|
|
WOS 分野
|
ENGINEERING, BIOMEDICAL
MATERIALS SCIENCE, BIOMATERIALS
|
| リソース情報 |
| ヒト・動物細胞 |
MC3T3-E1(RCB1126) |
