論文 - 詳細
| RRC ID | 43785 |
|---|---|
| 著者 | Kimura K, Minamikawa Y, Ogasawara Y, Yoshida J, Saitoh K, Shinden H, Ye YQ, Takahashi S, Miyakawa T, Koshino H. |
| タイトル | Kujigamberol, a new dinorlabdane diterpenoid isolated from 85million years old Kuji amber using a biotechnological assay. |
| ジャーナル | Fitoterapia |
| Abstract |
A new compound, 15,20-dinor-5,7,9-labdatriene-18-ol (1), named kujigamberol, was isolated from amber, fossilized tree resin from the Kuji area in Japan, has been dated as being 85 million years old (late Cretaceous). Kujigamberol was identified using the hypersensitive mutant yeast (zds1∆ erg3∆ pdr1∆ pdr3∆) with respect to Ca(2+)-signal transduction. The structure was elucidated on the basis of spectroscopic analysis including 1D NMR, 2D NMR and HR-EI-MS. It was different from known diterpenoids with a similar activity isolated from Baltic amber (agathic acid 15-monomethyl ester (2), dehydroabietic acid (3) and pimaric acid (4)). Kujigamberol showed glycogen synthase kinase-3β (GSK-3β) inhibition activity involving the growth restored activity against the mutant yeast and was cytotoxic to HL60 cells (IC(50)=19.6 μM). |
| 巻・号 | 83(5) |
| ページ | 907-12 |
| 公開日 | 2012-7-1 |
| DOI | 10.1016/j.fitote.2012.03.024 |
| PII | S0367-326X(12)00090-1 |
| PMID | 22507387 |
| MeSH | Amber / chemistry* Antineoplastic Agents, Phytogenic / isolation & purification* Antineoplastic Agents, Phytogenic / pharmacology Antineoplastic Agents, Phytogenic / therapeutic use Calcium / metabolism Diterpenes / isolation & purification* Diterpenes / pharmacology Diterpenes / therapeutic use Enzyme Inhibitors / isolation & purification* Enzyme Inhibitors / pharmacology Enzyme Inhibitors / therapeutic use Fossils* Glycogen Synthase Kinase 3 / antagonists & inhibitors Glycogen Synthase Kinase 3 beta HL-60 Cells Humans Japan Molecular Structure Phytotherapy* Plant Extracts / chemistry* Plant Extracts / pharmacology Plant Extracts / therapeutic use Signal Transduction Yeasts |
| IF | 2.527 |
| 引用数 | 24 |
| WOS 分野 | PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| リソース情報 | |
| ヒト・動物細胞 | |