論文 - 詳細
| RRC ID | 43793 |
|---|---|
| 著者 | Murata K, Noguchi K, Kondo M, Onishi M, Watanabe N, Okamura K, Matsuda H. |
| タイトル | Promotion of hair growth by Rosmarinus officinalis leaf extract. |
| ジャーナル | Phytother Res |
| Abstract |
Topical administration of Rosmarinus officinalis leaf extract (RO-ext, 2 mg/day/mouse) improved hair regrowth in C57BL/6NCrSlc mice that experienced hair regrowth interruption induced by testosterone treatment. In addition, RO-ext promoted hair growth in C3H/He mice that had their dorsal areas shaved. To investigate the antiandrogenic activity mechanism of RO-ext, we focused on inhibition of testosterone 5α-reductase, which is well recognized as one of the most effective strategies for the treatment of androgenic alopecia. RO-ext showed inhibitory activity of 82.4% and 94.6% at 200 and 500 µg/mL, respectively. As an active constituent of 5α-reductase inhibition, 12-methoxycarnosic acid was identified with activity-guided fractionation. In addition, the extract of R. officinalis and 12-methoxycarnosic acid inhibited androgen-dependent proliferation of LNCaP cells as 64.5% and 66.7% at 5 µg/mL and 5 μM, respectively. These results suggest that they inhibit the binding of dihydrotestosterone to androgen receptors. Consequently, RO-ext is a promising crude drug for hair growth. |
| 巻・号 | 27(2) |
| ページ | 212-7 |
| 公開日 | 2013-2-1 |
| DOI | 10.1002/ptr.4712 |
| PMID | 22517595 |
| MeSH | 5-alpha Reductase Inhibitors / pharmacology* Alopecia / chemically induced Alopecia / drug therapy Androgen Antagonists / pharmacology Animals Cell Line, Tumor Hair / drug effects* Hair / growth & development Humans Male Mice Mice, Inbred C3H Mice, Inbred C57BL Phytotherapy Plant Extracts / pharmacology* Plant Leaves / chemistry Rats Rats, Wistar Rosmarinus / chemistry* Testosterone / pharmacology |
| IF | 4.087 |
| 引用数 | 18 |
| WOS 分野 | PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Google+ |
| 各媒体での言及数の合計 | 336 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 30.5 |
| リソース情報 | |
| ヒト・動物細胞 | LNCap.FGC(RCB2144) |