RRC ID 43864
著者 Hong A, Han DD, Wright CJ, Burch T, Piper J, Osiowy C, Gao C, Chiang S, Magill T, Dick K, Booth TF, Li X, He R.
タイトル The interaction between hepatitis B virus X protein and AIB1 oncogene is required for the activation of NFκB signal transduction.
ジャーナル Biochem Biophys Res Commun
Abstract We identified the interaction between HBV X (HBx) protein and the oncogene AIB1 (amplified in breast cancer 1). A serine/proline motif (SSPSPS) in HBx was found to be required for the interaction. Two LXD motifs [LLXX(X)L, X means any amino acids], LLRNSL and LLDQLHTLL in AIB1 were also found to be involved in the HBx-AIB1 interaction. The HBx-AIB1 interaction was important for the activation of NFκB signal transduction, the HBx mutant that did not interact with AIB1showed dramatically lower NFκB activation activity than the WT HBx. These findings contribute to the new understanding on signal transduction activation mechanisms of HBx.
巻・号 423(1)
ページ 6-12
公開日 2012-6-22
DOI 10.1016/j.bbrc.2012.05.021
PII S0006-291X(12)00885-6
PMID 22627138
MeSH Amino Acid Sequence Carcinogens* Carcinoma, Hepatocellular / genetics Carcinoma, Hepatocellular / metabolism Cell Line, Tumor Conserved Sequence Humans Molecular Sequence Data Mutation NF-kappa B / metabolism* Nuclear Receptor Coactivator 3 / genetics Nuclear Receptor Coactivator 3 / metabolism* Protein Interaction Domains and Motifs Serine / genetics Serine / metabolism Signal Transduction Trans-Activators / genetics Trans-Activators / metabolism* Two-Hybrid System Techniques Viral Regulatory and Accessory Proteins
IF 2.985
引用数 6
WOS 分野 BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
ヒト・動物細胞