| RRC ID |
43902
|
| 著者 |
Atsumi S, Matsumine A, Toyoda H, Niimi R, Iino T, Nakamura T, Matsubara T, Asanuma K, Komada Y, Uchida A, Sudo A.
|
| タイトル |
Oncolytic virotherapy for human bone and soft tissue sarcomas using live attenuated poliovirus.
|
| ジャーナル |
Int J Oncol
|
| Abstract |
The poliovirus receptor CD155, is essential for poliovirus to infect and induce death in neural cells. Recently, CD155 has been shown to be selectively expressed on certain types of tumor cells originating from the neural crest, including malignant glioma and neuroblastoma. However, the expression pattern of CD155 in soft tissue sarcoma has not been examined. Therefore, we first examined CD155 expression in sarcoma cell lines, and found the expression of both CD155 mRNA and protein in 12 soft and bone tissue sarcoma cell lines. Furthermore, we examined the effect of live attenuated poliovirus (LAPV) on 6 bone and soft tissue sarcoma cell lines in vitro, and found that LAPV induced apoptosis by activating caspases 7 and 3 in all of these cell lines. Furthermore, in BALB/c nu/nu mice xenotransplanted with HT1080 fibrosarcoma cells, administration of live attenuated poliovirus caused growth suppression of the tumors. These results suggest that oncolytic therapy using a LAPV may represent a new option for the treatment of bone and soft tissue sarcomas.
|
| 巻・号 |
41(3)
|
| ページ |
893-902
|
| 公開日 |
2012-9-1
|
| DOI |
10.3892/ijo.2012.1514
|
| PMID |
22692919
|
| MeSH |
Animals
Apoptosis
Bone Neoplasms / therapy*
Caspase 3 / biosynthesis
Caspase 7 / biosynthesis
Cell Line, Tumor
Humans
Mice
Oncolytic Virotherapy / methods*
Oncolytic Viruses* / pathogenicity
Osteosarcoma / therapy*
Poliovirus* / pathogenicity
RNA, Messenger / genetics
RNA, Messenger / metabolism
Receptors, Virus / biosynthesis
Receptors, Virus / genetics*
Sarcoma / therapy*
Xenograft Model Antitumor Assays
|
| IF |
3.899
|
| 引用数 |
11
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
143B/TK^(-)neo^(R)(RCB0701)
Saos-2(RCB0426)
HOS(RCB0992) |
