論文 - 詳細
| RRC ID | 43984 |
|---|---|
| 著者 | Rahman MT, Nakayama K, Rahman M, Katagiri H, Katagiri A, Ishibashi T, Ishikawa M, Iida K, Nakayama N, Otsuki Y, Nakayama S, Miyazaki K. |
| タイトル | Gene amplification of ZNF217 located at chr20q13.2 is associated with lymph node metastasis in ovarian clear cell carcinoma. |
| ジャーナル | Anticancer Res |
| Abstract |
BACKGROUND:Recently we reported that amplification of the Zinc Finger Protein 217 (ZNF217) gene adversely affects survival of patients with ovarian clear cell carcinoma. This study sought to determine the mechanism by which ZNF217 amplification affects patient survival. MATERIALS AND METHODS:Fluorescence in situ hybridization (FISH) was used to detect ZNF217 gene amplification status and ZNF217-specific siRNA was used to inactivate ZNF217 for in vitro biological analyses. RESULTS:We found ZNF217 gene amplification to be significantly correlated with lymph node metastasis (p<0.05) in ovarian clear cell carcinoma. Profound inhibition of cell migration and invasion was observed in siRNA-treated cells with ZNF217 amplification, compared to cells without amplification. CONCLUSION:These findings provide new insight into the biological role of ZNF217 gene amplification in ovarian clear cell carcinoma. Additionally, our observations have an important therapeutic implication for patients with ovarian clear cell carcinomas with ZNF217 amplification, as these patients may potentially benefit from ZNF217 targeted-therapy. |
| 巻・号 | 32(8) |
| ページ | 3091-5 |
| 公開日 | 2012-8-1 |
| PII | 32/8/3091 |
| PMID | 22843878 |
| MeSH | Chromosomes, Human, Pair 20* Female Gene Amplification* Humans Immunohistochemistry In Situ Hybridization, Fluorescence Lymphatic Metastasis Ovarian Neoplasms / genetics* Ovarian Neoplasms / pathology* RNA, Small Interfering Trans-Activators / genetics* |
| IF | 1.994 |
| 引用数 | 12 |
| WOS 分野 | ONCOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | |