論文 - 詳細
| RRC ID | 44063 |
|---|---|
| 著者 | Jing X, Miyajima M, Sawada T, Chen Q, Iida K, Furushima K, Arai D, Chihara K, Sakaguchi K. |
| タイトル | Crosstalk of humoral and cell-cell contact-mediated signals in postnatal body growth. |
| ジャーナル | Cell Rep |
| Abstract |
The growth hormone (GH)-insulin-like growth factor 1 (IGF1) axis mediates postnatal body growth. The GH receptor has been regarded as the sole receptor that mediates the Janus kinase 2 (JAK2)/signal transducers and activators of the transcription 5B (STAT5B) signal toward IGF1 synthesis. Here, we report a signaling pathway that regulates postnatal body growth through EphA4, a member of the Eph family of receptor tyrosine kinases and a mediator of the cell-cell contact-mediated signaling. EphA4 forms a complex with the GH receptor, JAK2, and STAT5B and enhances Igf1 expression predominantly via the JAK2-dependent pathway, with some direct effect on STAT5B. Mice with a defective Epha4 gene have a gene dose-dependent short stature and low plasma IGF1 levels. Igf1 messenger RNA (mRNA) in the liver and many other tissues was also significantly reduced in Epha4-knockout mice, whereas pituitary Gh mRNA and plasma GH levels were not. These findings suggest that the local cell-cell contact-mediated ephrin/EphA4 signal is as important as the humoral GH signal in IGF1 synthesis and body size determination. |
| 巻・号 | 2(3) |
| ページ | 652-65 |
| 公開日 | 2012-9-27 |
| DOI | 10.1016/j.celrep.2012.08.021 |
| PII | S2211-1247(12)00261-6 |
| PMID | 22999939 |
| MeSH | Animals Body Size / physiology* Cell Communication / physiology* Gene Dosage Growth Hormone / genetics Growth Hormone / metabolism* Humans Insulin-Like Growth Factor I / genetics Insulin-Like Growth Factor I / metabolism* Janus Kinase 2 / genetics Janus Kinase 2 / metabolism Mice Mice, Mutant Strains RNA, Messenger / genetics RNA, Messenger / metabolism Receptor, EphA4 / genetics Receptor, EphA4 / metabolism Receptors, Somatotropin / genetics Receptors, Somatotropin / metabolism* STAT5 Transcription Factor / genetics STAT5 Transcription Factor / metabolism Signal Transduction / physiology* |
| IF | 8.109 |
| 引用数 | 12 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | Hep G2 |