論文 - 詳細
| RRC ID | 4409 |
|---|---|
| 著者 | Shteingauz A, Cohen E, Biala Y, Treinin M. |
| タイトル | The BTB-MATH protein BATH-42 interacts with RIC-3 to regulate maturation of nicotinic acetylcholine receptors. |
| ジャーナル | J Cell Sci |
| Abstract |
RIC-3 is a member of a conserved family of proteins that affect nicotinic acetylcholine receptor maturation. In yeast and in vitro, BATH-42, a BTB- and MATH-domain-containing protein, interacts with RIC-3. BATH-42 is also known to interact with the CUL-3 ubiquitin ligase complex. Loss of BATH-42 function leads to increased RIC-3 expression and decreased activity of nicotinic acetylcholine receptors in Caenorhabditis elegans vulva muscles. Increased expression of RIC-3 is deleterious for activity and distribution of nicotinic acetylcholine receptors, and thus the effects of BATH-42 loss of function on RIC-3 expression explain the associated reduction in receptor activity. Overexpression of BATH-42 is also detrimental to nicotinic acetylcholine receptor function, leading to decreased pharyngeal pumping. This effect depends on the C-terminus of RIC-3 and on CUL-3. Thus, our work suggests that BATH-42 targets RIC-3 to degradation via CUL-3-mediated ubiquitylation. This demonstrates the importance of regulation of RIC-3 levels, and identifies a mechanism that protects cells from the deleterious effects of excess RIC-3. |
| 巻・号 | 122(Pt 6) |
| ページ | 807-12 |
| 公開日 | 2009-3-15 |
| DOI | 10.1242/jcs.036343 |
| PII | jcs.036343 |
| PMID | 19223395 |
| MeSH | Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / drug effects Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / chemistry* Caenorhabditis elegans Proteins / metabolism* Carrier Proteins / chemistry* Carrier Proteins / metabolism* Female Levamisole / pharmacology Muscles / cytology Muscles / drug effects Muscles / metabolism Mutation / genetics Pharynx / cytology Pharynx / metabolism Protein Binding Protein Structure, Tertiary Protein Transport / drug effects Receptors, Nicotinic / metabolism* Vulva / cytology Vulva / drug effects Vulva / metabolism |
| IF | 4.573 |
| 引用数 | 12 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 線虫 | tm2360 |