論文 - 詳細
| RRC ID | 44129 |
|---|---|
| 著者 | Awale S, Ueda JY, Athikomkulchai S, Dibwe DF, Abdelhamed S, Yokoyama S, Saiki I, Miyatake R. |
| タイトル | Uvaridacols E-H, highly oxygenated antiausterity agents from Uvaria dac. |
| ジャーナル | J Nat Prod |
| Abstract |
Chemical investigation of the stems of Uvaria dac yielded four new highly oxygenated cyclohexene derivatives named uvaridacols E-H (1-4). Their structures were established through NMR and circular dichroism spectroscopic analysis. Uvaridacols E (1), F (2), and H (4) displayed weak preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions in a concentration-dependent manner, without causing toxicity in normal nutrient-rich conditions. |
| 巻・号 | 75(11) |
| ページ | 1999-2002 |
| 公開日 | 2012-11-26 |
| DOI | 10.1021/np300596c |
| PMID | 23092429 |
| MeSH | Antineoplastic Agents, Phytogenic / chemistry Antineoplastic Agents, Phytogenic / isolation & purification* Antineoplastic Agents, Phytogenic / pharmacology* Cyclohexenes / chemistry Cyclohexenes / isolation & purification* Cyclohexenes / pharmacology* Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pancreatic Neoplasms / drug therapy Plant Stems / chemistry Thailand Uvaria / chemistry* |
| IF | 3.782 |
| 引用数 | 15 |
| WOS 分野 | PLANT SCIENCES PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Google+ |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | PANC-1(RCB2095) |