| RRC ID |
44129
|
| Author |
Awale S, Ueda JY, Athikomkulchai S, Dibwe DF, Abdelhamed S, Yokoyama S, Saiki I, Miyatake R.
|
| Title |
Uvaridacols E-H, highly oxygenated antiausterity agents from Uvaria dac.
|
| Journal |
J Nat Prod
|
| Abstract |
Chemical investigation of the stems of Uvaria dac yielded four new highly oxygenated cyclohexene derivatives named uvaridacols E-H (1-4). Their structures were established through NMR and circular dichroism spectroscopic analysis. Uvaridacols E (1), F (2), and H (4) displayed weak preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions in a concentration-dependent manner, without causing toxicity in normal nutrient-rich conditions.
|
| Volume |
75(11)
|
| Pages |
1999-2002
|
| Published |
2012-11-26
|
| DOI |
10.1021/np300596c
|
| PMID |
23092429
|
| MeSH |
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology*
Cyclohexenes / chemistry
Cyclohexenes / isolation & purification*
Cyclohexenes / pharmacology*
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pancreatic Neoplasms / drug therapy
Plant Stems / chemistry
Thailand
Uvaria / chemistry*
|
| IF |
3.782
|
| Times Cited |
15
|
|
WOS Category
|
PLANT SCIENCES
PHARMACOLOGY & PHARMACY
CHEMISTRY, MEDICINAL
|
| Resource |
| Human and Animal Cells |
PANC-1(RCB2095) |
