| RRC ID |
44236
|
| Author |
Hanada S, Fujioka K, Futamura Y, Manabe N, Hoshino A, Yamamoto K.
|
| Title |
Evaluation of anti-inflammatory drug-conjugated silicon quantum dots: their cytotoxicity and biological effect.
|
| Journal |
Int J Mol Sci
|
| Abstract |
Silicon quantum dots (Si-QDs) have great potential for biomedical applications, including their use as biological fluorescent markers and carriers for drug delivery systems. Biologically inert Si-QDs are less toxic than conventional cadmium-based QDs, and can modify the surface of the Si-QD with covalent bond. We synthesized water-soluble alminoprofen-conjugated Si-QDs (Ap-Si). Alminoprofen is a non-steroid anti-inflammatory drug (NSAID) used as an analgesic for rheumatism. Our results showed that the "silicon drug" is less toxic than the control Si-QD and the original drug. These phenomena indicate that the condensed surface integration of ligand/receptor-type drugs might reduce the adverse interaction between the cells and drug molecules. In addition, the medicinal effect of the Si-QDs (i.e., the inhibition of COX-2 enzyme) was maintained compared to that of the original drug. The same drug effect is related to the integration ratio of original drugs, which might control the binding interaction between COX-2 and the silicon drug. We conclude that drug conjugation with biocompatible Si-QDs is a potential method for functional pharmaceutical drug development.
|
| Volume |
14(1)
|
| Pages |
1323-34
|
| Published |
2013-1-10
|
| DOI |
10.3390/ijms14011323
|
| PII |
ijms14011323
|
| PMID |
23306154
|
| PMC |
PMC3565323
|
| MeSH |
Anti-Inflammatory Agents, Non-Steroidal / chemistry*
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
Arachidonic Acid / metabolism
Biocatalysis / drug effects
Cell Survival / drug effects
Cyclooxygenase 2 / metabolism
Cyclooxygenase 2 Inhibitors / chemistry
Cyclooxygenase 2 Inhibitors / pharmacology
Dinoprost / metabolism
Drug Evaluation, Preclinical
Enzyme-Linked Immunosorbent Assay
Hep G2 Cells
Humans
Kinetics
Microscopy, Electron, Transmission
Propionates / chemistry*
Propionates / pharmacology
Proton Magnetic Resonance Spectroscopy
Quantum Dots*
Silicon / chemistry*
Spectroscopy, Fourier Transform Infrared
|
| IF |
4.556
|
| Times Cited |
18
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CHEMISTRY, MULTIDISCIPLINARY
|
| Resource |
| Human and Animal Cells |
Hep G2(RCB1648) |
