Reference - Detail
| RRC ID | 44243 |
|---|---|
| Author | Goto H, Matsuda K, Srikoon P, Kariya R, Hattori S, Taura M, Katano H, Okada S. |
| Title | Potent antitumor activity of zoledronic acid-induced Vγ9Vδ2 T cells against primary effusion lymphoma. |
| Journal | Cancer Lett |
| Abstract |
Primary effusion lymphoma (PEL) is a subtype of aggressive and resistant non-Hodgkin lymphoma that occurs predominantly in patients with advanced AIDS. In this study, we examined the antitumor activity of zoledronic acid (Zol)-induced Vγ9Vδ2 T cells against PEL cells in vitro and in vivo. Vγ9Vδ2 T cells recognized endogenous mevalonate metabolites and MICA/B of PEL cell lines, inducing cytotoxicity via granule exocytosis and TRAIL-mediated pathway. Vγ9Vδ2 T cells suppressed the development of PEL cells and existed in a PEL xenograft mouse model. These results show that immunotherapy with Zol-induced Vγ9Vδ2 T cells could demonstrate an efficient strategy for PEL. |
| Volume | 331(2) |
| Pages | 174-82 |
| Published | 2013-5-1 |
| DOI | 10.1016/j.canlet.2012.12.021 |
| PII | S0304-3835(13)00005-0 |
| PMID | 23321500 |
| MeSH | Animals Cell Proliferation / drug effects Diphosphonates / pharmacology Diphosphonates / therapeutic use* Flow Cytometry Humans Imidazoles / pharmacology Imidazoles / therapeutic use* Immunohistochemistry Lymphoma, Primary Effusion / immunology Lymphoma, Primary Effusion / therapy* Mice Mice, Inbred NOD T-Lymphocytes / cytology T-Lymphocytes / drug effects* T-Lymphocytes / immunology Xenograft Model Antitumor Assays Zoledronic Acid |
| IF | 7.36 |
| Times Cited | 9 |
| WOS Category | ONCOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Resource | |
| Human and Animal Cells | DAUDI(RCB1640) |