RRC ID 44261
著者 Akiyama K, Ohga N, Maishi N, Hida Y, Kitayama K, Kawamoto T, Osawa T, Suzuki Y, Shinohara N, Nonomura K, Shindoh M, Hida K.
タイトル The F-prostaglandin receptor is a novel marker for tumor endothelial cells in renal cell carcinoma.
ジャーナル Pathol Int
Abstract Tumor angiogenesis is necessary for tumor progression and metastasis; therefore, tumor blood vessels are potential therapeutic targets in anticancer therapy. We previously reported that tumor endothelial cells (TECs) exhibit different phenotypes compared with normal endothelial cells (NECs), and microarray analyses of mouse TECs and NECs have shown that several genes are upregulated in TECs compared with NECs. Among these genes, the expression levels of prostaglandin F receptor (PTGFR) mRNA, which encodes the prostaglandin F receptor (FP), were higher in TECs than in NECs. It has been reported that FP and its ligand, prostaglandin F(2α) , are involved in tumor angiogenesis. However, there have been no reports of the expression of PTGFR in the tumor vessels of renal cell carcinoma (RCC). Thus, we isolated human TECs (hTECs) from RCCs. The expression levels of PTGFR mRNA were also upregulated in hTECs. In addition, immunostaining showed that the PTGFR was expressed in human tumor blood vessels in vivo. These findings suggested that PTGFR is a novel TEC marker and that it may be a novel target for antiangiogenic therapy for RCC.
巻・号 63(1)
ページ 37-44
公開日 2013-1-1
DOI 10.1111/pin.12031
PMID 23356224
MeSH Animals Biomarkers, Tumor / metabolism Carcinoma, Renal Cell / blood supply* Carcinoma, Renal Cell / pathology Cell Line, Tumor Endothelium, Vascular / metabolism* Endothelium, Vascular / pathology Humans Kidney Neoplasms / blood supply* Kidney Neoplasms / pathology Mice Neovascularization, Pathologic / metabolism* Neovascularization, Pathologic / pathology Nephrectomy RNA, Messenger / metabolism Receptors, Prostaglandin / genetics Receptors, Prostaglandin / metabolism* Up-Regulation
IF 2.11
引用数 8
WOS 分野 PATHOLOGY
リソース情報
ヒト・動物細胞 OS-RC-2(RCB0735)