Reference - Detail
|Author||Nakamura S, Nakashima S, Oda Y, Yokota N, Fujimoto K, Matsumoto T, Ohta T, Ogawa K, Maeda S, Nishida S, Matsuda H, Yoshikawa M.|
|Title||Alkaloids from Sri Lankan curry-leaf (Murraya koenigii) display melanogenesis inhibitory activity: structures of karapinchamines A and B.|
|Journal||Bioorg. Med. Chem.|
A methanolic extract and its ethyl acetate-soluble fraction from Sri Lankan curry-leaf, the leaves of Murraya koenigii, inhibited melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. Two new carbazole alkaloids, karapinchamines A and B, were isolated from the ethyl acetate-soluble fraction together with 12 known carbazole alkaloids. The structures of karapinchamines A and B were determined by physicochemical analyses. The principal alkaloid constituents were found to display potent melanogenesis inhibitory activity. The structural requirements of the carbazole alkaloids for melanogenesis inhibitory activity were discussed.
|MeSH||Acetates / chemistry Alkaloids / chemistry* Alkaloids / isolation & purification Alkaloids / pharmacology* Animals Carbazoles / chemistry* Carbazoles / isolation & purification Carbazoles / pharmacology Cell Differentiation / drug effects Cell Line, Tumor Chemical Fractionation Gene Expression Regulation / drug effects Magnetic Resonance Spectroscopy Melanins / metabolism Mice Molecular Conformation Murraya / chemistry* Plant Extracts / chemistry* Plant Extracts / pharmacology* Plant Leaves / chemistry|
|WOS Category||CHEMISTRY, MEDICINAL CHEMISTRY, ORGANIC BIOCHEMISTRY & MOLECULAR BIOLOGY|
|Human and Animal Cells|