RRC ID 44284
Author Nakamura S, Nakashima S, Oda Y, Yokota N, Fujimoto K, Matsumoto T, Ohta T, Ogawa K, Maeda S, Nishida S, Matsuda H, Yoshikawa M.
Title Alkaloids from Sri Lankan curry-leaf (Murraya koenigii) display melanogenesis inhibitory activity: structures of karapinchamines A and B.
Journal Bioorg. Med. Chem.
Abstract A methanolic extract and its ethyl acetate-soluble fraction from Sri Lankan curry-leaf, the leaves of Murraya koenigii, inhibited melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. Two new carbazole alkaloids, karapinchamines A and B, were isolated from the ethyl acetate-soluble fraction together with 12 known carbazole alkaloids. The structures of karapinchamines A and B were determined by physicochemical analyses. The principal alkaloid constituents were found to display potent melanogenesis inhibitory activity. The structural requirements of the carbazole alkaloids for melanogenesis inhibitory activity were discussed.
Volume 21(5)
Pages 1043-9
Published 2013-3-1
DOI 10.1016/j.bmc.2013.01.012
PII S0968-0896(13)00041-2
PMID 23376010
MeSH Acetates / chemistry Alkaloids / chemistry* Alkaloids / isolation & purification Alkaloids / pharmacology* Animals Carbazoles / chemistry* Carbazoles / isolation & purification Carbazoles / pharmacology Cell Differentiation / drug effects Cell Line, Tumor Chemical Fractionation Gene Expression Regulation / drug effects Magnetic Resonance Spectroscopy Melanins / metabolism Mice Molecular Conformation Murraya / chemistry* Plant Extracts / chemistry* Plant Extracts / pharmacology* Plant Leaves / chemistry
IF 2.881
Times Cited 17
WOS Category CHEMISTRY, MEDICINAL CHEMISTRY, ORGANIC BIOCHEMISTRY & MOLECULAR BIOLOGY
Resource
Human and Animal Cells