RRC ID 44285
Author Zhao S, Liu H, Liu Y, Wu J, Wang C, Hou X, Chen X, Yang G, Zhao L, Che H, Bi Y, Wang H, Peng F, Ai J.
Title miR-143 inhibits glycolysis and depletes stemness of glioblastoma stem-like cells.
Journal Cancer Lett
Abstract Glioblastomas rely mainly on aerobic glycolysis to sustain proliferation and growth; however, little is known about the regulatory mechanisms of metabolism in glioblastoma stem cells. We show that miR-143 is significantly down-regulated in glioma tissues and glioblastoma stem-like cells (GSLCs), while miR-143 over-expression inhibits glycolysis by directly targeting hexokinase 2, and promotes differentiation of GSLCs. Moreover, miR-143 inhibits proliferation of GSLCs under hypoxic conditions and decreases tumor formation capacity of GSLCs in vivo. We also show that a combination of miR-143 and 2-DG, a widely used glycolysis inhibitor, has synergistic effects against GSLCs. miR-143 is a potential therapeutic target for glioblastoma treatment.
Volume 333(2)
Pages 253-60
Published 2013-6-10
DOI 10.1016/j.canlet.2013.01.039
PII S0304-3835(13)00085-2
PMID 23376635
MeSH Animals Base Sequence Cell Differentiation / genetics Cell Hypoxia / genetics Cell Line, Tumor Deoxyglucose / pharmacology Female Glioblastoma / drug therapy Glioblastoma / genetics Glioblastoma / pathology Glioma / genetics* Glioma / pathology* Glycolysis / genetics Humans Mice Mice, Inbred BALB C MicroRNAs / genetics* Molecular Sequence Data Neoplastic Stem Cells / drug effects Neoplastic Stem Cells / pathology* Rats
IF 7.36
Times Cited 52
Human and Animal Cells