論文 - 詳細
| RRC ID | 44285 |
|---|---|
| 著者 | Zhao S, Liu H, Liu Y, Wu J, Wang C, Hou X, Chen X, Yang G, Zhao L, Che H, Bi Y, Wang H, Peng F, Ai J. |
| タイトル | miR-143 inhibits glycolysis and depletes stemness of glioblastoma stem-like cells. |
| ジャーナル | Cancer Lett |
| Abstract |
Glioblastomas rely mainly on aerobic glycolysis to sustain proliferation and growth; however, little is known about the regulatory mechanisms of metabolism in glioblastoma stem cells. We show that miR-143 is significantly down-regulated in glioma tissues and glioblastoma stem-like cells (GSLCs), while miR-143 over-expression inhibits glycolysis by directly targeting hexokinase 2, and promotes differentiation of GSLCs. Moreover, miR-143 inhibits proliferation of GSLCs under hypoxic conditions and decreases tumor formation capacity of GSLCs in vivo. We also show that a combination of miR-143 and 2-DG, a widely used glycolysis inhibitor, has synergistic effects against GSLCs. miR-143 is a potential therapeutic target for glioblastoma treatment. |
| 巻・号 | 333(2) |
| ページ | 253-60 |
| 公開日 | 2013-6-10 |
| DOI | 10.1016/j.canlet.2013.01.039 |
| PII | S0304-3835(13)00085-2 |
| PMID | 23376635 |
| MeSH | Animals Base Sequence Cell Differentiation / genetics Cell Hypoxia / genetics Cell Line, Tumor Deoxyglucose / pharmacology Female Glioblastoma / drug therapy Glioblastoma / genetics Glioblastoma / pathology Glioma / genetics* Glioma / pathology* Glycolysis / genetics Humans Mice Mice, Inbred BALB C MicroRNAs / genetics* Molecular Sequence Data Neoplastic Stem Cells / drug effects Neoplastic Stem Cells / pathology* Rats |
| IF | 7.36 |
| 引用数 | 52 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | U-87 MG(RCB0429) C6(RCB2854) |